1-羟基环丙烷羧酸甲酯
Methyl 1-hydroxycyclopropanecarboxylate
CAS: 33689-29-1
Molecular Formula: C5H8O3
1-羟基环丙烷羧酸甲酯 - Names and Identifiers
1-羟基环丙烷羧酸甲酯 - Physico-chemical Properties
| Molecular Formula | C5H8O3 |
| Molar Mass | 116.12 |
| Density | 1.346±0.06 g/cm3(Predicted) |
| Boling Point | 70°C/13mmHg |
| Flash Point | 17℃ |
| Solubility | Dichloromethane, Methanol |
| Vapor Presure | 3.47mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear yellow |
| pKa | 13.14±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.521 |
1-羟基环丙烷羧酸甲酯 - Risk and Safety
| Risk Codes | 11 - Highly Flammable |
| Safety Description | 16 - Keep away from sources of ignition. |
| UN IDs | 3277 |
| HS Code | 29162090 |
1-羟基环丙烷羧酸甲酯 - Reference Information
| Introduction | Methyl 1-hydroxy-1-cycloprocarboxylate is an organic intermediate. Because many compounds containing cyclopropane substructural units have good biological activity, cyclopropane has a very wide range of applications in drug design. |
| Uses | Methyl 1-hydroxy-1-cycloprocarboxylate is a carboxylate organic substance and can be used as an intermediate in organic synthesis. |
| preparation | 1-aminocyclopropyl methyl ester (3.41g,29.6mmol,1.0eq) is dissolved in 40ml of sulfuric acid aqueous solution a (1.62mL of 98% concentrated sulfuric acid is added to water to prepare, the molar equivalent of sulfuric acid is 1.0eq), the ice bath is cooled to 0-5 ℃, and 10ml of sodium nitrite (2.25g,32.6mmol,1.1eq) aqueous solution, stirring at room temperature for 1 hour. Then the above reaction droplets are added to the refluxed 100ml sulfuric acid aqueous solution B (obtained by adding 1.62mL 98% concentrated sulfuric acid into water, and the molar equivalent of sulfuric acid is 1.0eq). After dropping, stop heating and cool to room temperature. After TLC detection reaction is completed, ethyl acetate (3*100mL) is extracted three times, the organic phase is combined, dried with anhydrous magnesium sulfate, filtered and concentrated the organic phase to obtain methyl 1-hydroxy -1-cycloprocarboxylate (2.57g,22.1mmol), colorless oily liquid, and the yield is 74.8%. |
Last Update：2024-04-09 21:01:54
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View History
1-羟基环丙烷羧酸甲酯
哌马色林
7-Trihydroxyxanthone
AKOS B022434
他克莫司相关化合物A(子囊霉素)
BISPHENOL A BIS(2,3-DIHYDROXYPROPYL) ETHER
Tetraphenylphosphorane hydrobromide
L-ALPHA-CHLOROPROPIONIC ACID
对碘苯基硼酸
CYCLO(-PHE-PHE)
哌马色林
7-Trihydroxyxanthone
AKOS B022434
他克莫司相关化合物A(子囊霉素)
BISPHENOL A BIS(2,3-DIHYDROXYPROPYL) ETHER
Tetraphenylphosphorane hydrobromide
L-ALPHA-CHLOROPROPIONIC ACID
对碘苯基硼酸
CYCLO(-PHE-PHE)