1015460-59-9

Name	7-BROMO-5H-PYRIDO[4,3-B]INDOLE
Synonyms	7-BROMO-5H-PYRIDO[4,3-B]INDOLE 5H-Pyrido[4,3-b]indole, 7-bromo-
CAS	1015460-59-9

Molecular Formula	C11H7BrN2
Molar Mass	247.09
Density	1.699±0.06 g/cm3(Predicted)
Boling Point	443.6±25.0 °C(Predicted)
pKa	14.04±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature

Application	7-bromo-5H-pyridino [4,3-B] indole is a pharmaceutical intermediate, which can be composed of 3-bromo-4-Nitropyridine and 4-bromophenylboronic acid react through Suzuki to obtain 3-(4-bromobenzene)-4-nitropyridine, then the ring is closed to obtain 7-bromo-5H-pyrido [4,3-B] indole.
Uses	7-bromo-5H-pyridino [4,3-B] indole is a heterocyclic organic substance, mainly used as a pharmaceutical intermediate.
preparation	step 1. preparation of 3-(4-bromobenzene)-4-nitropyridine 2.02g(10.0mmol) 3-bromo-4-nitropyridine, 2.20g(11.0mmol) 4-bromophenylboronic acid, 0.46g(0.4mmol) tetraphenylphosphine palladium, 1.33g(25mmol)NaCO3 is dissolved in 60mL of dioxane and 10mL of water, refluxed at 110 ℃ for 12h, cooled, poured into 80mL of water, then extracted with 100mL of ethyl acetate for three times, and dried with anhydrous magnesium sulfate. The solvent was removed in vacuum, and the solid was separated by column chromatography to obtain 2.1g of yellow solid product (yield: 75%). The preparation of 7-bromo-5H-pyridino [4,3-B] indole was 2..1.68g 3-(4-bromobenzene)-4-nitropyridine was dissolved in 60mL triethyl phosphite, heated at 110 ℃ for 3h under nitrogen protection, cooled, and the obtained solid was separated by column chromatography, 1.05g of brown-yellow solid product (yield: 71%) was obtained.

Last Update：2024-04-09 21:04:16

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Product Name: 7-BROMO-5H-PYRIDO[4,3-B]INDOLE Visit Supplier Webpage Request for quotation
CAS: 1015460-59-9
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1015460-59-9

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