1015846-76-0
3-Chloro-6-methylpyrazolo[1,5-a]pyrimidine-2-carboxylic acid
CAS: 1015846-76-0
Molecular Formula: C8H6ClN3O2
1015846-76-0 - Names and Identifiers
1015846-76-0 - Physico-chemical Properties
| Molecular Formula | C8H6ClN3O2 |
| Molar Mass | 211.61 |
| Density | 1.65±0.1 g/cm3(Predicted) |
| pKa | -3.89±0.41(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD09971313 |
1015846-76-0 - Risk and Safety
| Hazard Class | IRRITANT |
1015846-76-0 - Introduction
[1,5-a]pyrimidine-2-carboxylic acid is an organic compound whose chemical formula is C8H6ClN3O2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline solid
-Melting point: 215-218°C
-Solubility: Soluble in some organic solvents, such as ethanol, dichloromethane and dimethyl sulfoxide
Use:
[1,5-a]pyrimidine-2-carboxylic acid is a commonly used organic synthesis intermediate, which is widely used in the manufacture of drugs and pesticides. It can be used as a precursor compound of a novel antitumor drug with anticancer activity. In addition, it can also be used for the synthesis of pyrazolo [1,5-a] pyrimidine antibacterial agents and antiviral drugs.
Preparation Method:
[1,5-a] The preparation method of pyrimidine-2-carboxylic acid mainly includes the following steps:
1.3-chloropyridine and 2-methyl pyridine are added in a suitable solvent to react to generate 3-chloro -6-methyl pyridine.
2. The above product is reacted with uracil under alkaline conditions to generate 3-chloro-6-methylpyrazolo [1,5-a] pyrimidine.
3. Finally, the product is reacted with acid to generate [1,5-a]pyrimidine-2-carboxylic acid.
Safety Information:
[1,5-a] The safety information of pyrimidine-2-carboxylic acid has not been fully evaluated, so it must be handled in accordance with laboratory and production practices. Wear appropriate personal protective equipment to avoid contact with skin, eyes and respiratory tract. If contact or inhalation occurs, rinse immediately with plenty of water and seek medical help.
Nature:
-Appearance: White crystalline solid
-Melting point: 215-218°C
-Solubility: Soluble in some organic solvents, such as ethanol, dichloromethane and dimethyl sulfoxide
Use:
[1,5-a]pyrimidine-2-carboxylic acid is a commonly used organic synthesis intermediate, which is widely used in the manufacture of drugs and pesticides. It can be used as a precursor compound of a novel antitumor drug with anticancer activity. In addition, it can also be used for the synthesis of pyrazolo [1,5-a] pyrimidine antibacterial agents and antiviral drugs.
Preparation Method:
[1,5-a] The preparation method of pyrimidine-2-carboxylic acid mainly includes the following steps:
1.3-chloropyridine and 2-methyl pyridine are added in a suitable solvent to react to generate 3-chloro -6-methyl pyridine.
2. The above product is reacted with uracil under alkaline conditions to generate 3-chloro-6-methylpyrazolo [1,5-a] pyrimidine.
3. Finally, the product is reacted with acid to generate [1,5-a]pyrimidine-2-carboxylic acid.
Safety Information:
[1,5-a] The safety information of pyrimidine-2-carboxylic acid has not been fully evaluated, so it must be handled in accordance with laboratory and production practices. Wear appropriate personal protective equipment to avoid contact with skin, eyes and respiratory tract. If contact or inhalation occurs, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 21:00:56
