101831-37-2
Diclazuril
CAS: 101831-37-2
Molecular Formula: C17H9Cl3N4O2
101831-37-2 - Names and Identifiers
| Name | Diclazuril |
| Synonyms | Nuoqiu Vecoxan CLINACOX DICLAZURIL Diclazuril DICLAZUTIL 2-[4-(4-Chloro-α-cyanobenzyl)-3,5-dichlorophenyl]-1,2,4-triazine-3,5(2H,4H)-dione 2-[3,5-Dichloro-4-(α-cyano-4-chlorobenzyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione 2,6-DICHLORO-A-(4-CHLOROPHENYL)-4(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN-2-YL)BENZENEACETONITRILE (4-chlorophenyl)[2,6-dichloro-3-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenyl]acetonitrile (4-chlorophenyl)[2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenyl]acetonitrile 2,6-Dichloro-a-(4-chlorophenyl)-4-[4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl]benzeneacetonitrile 2,6-dichloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3h)-yl)benzeneacetonitrile |
| CAS | 101831-37-2 |
| EINECS | 1806241-263-5 |
| InChI | InChI=1/C17H9Cl3N4O2/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24/h1-6,8,12H,(H,23,25,26) |
| InChIKey | ZSZFUDFOPOMEET-UHFFFAOYSA-N |
101831-37-2 - Physico-chemical Properties
| Molecular Formula | C17H9Cl3N4O2 |
| Molar Mass | 407.64 |
| Density | 1.56±0.1 g/cm3(Predicted) |
| Melting Point | 290.5° |
| Appearance | Pale yellow or white powder |
| Color | White to Light yellow to Light orange |
| Merck | 14,3080 |
| pKa | 5.89±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.701 |
| MDL | MFCD00867203 |
| Physical and Chemical Properties | Pale yellow or off-white powder, practically insoluble in water, slightly soluble in ethanol, ether, soluble in N,N-2 methyl Formamide (DMF), dimethyl sulphone (DMSO), tetrahydrofuran (THF). Melting Point: 291-297 ℃ |
| Use | Anti-coccidial drugs, have a control effect on a variety of coccidia |
101831-37-2 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | CY1697600 |
| HS Code | 29336990 |
101831-37-2 - Reference
| Reference Show more | 1. Li, Shasha, Fan Yin, and Dechao Rui. "Measurement of the Solubility of Diclazuril and Discussion of the Effect of the Cosolvent." Journal of Chemical & Engineering Data 64.8 (2019): 3585-3591.https://doi.org/10.1021/acs.jced.9b00353 |
101831-37-2 - Introduction
Almost insoluble in water, slightly soluble in ethanol, ether, soluble in N,N-2 methyl formamide (DMF), dimethyl sulfone (DMSO), tetrahydrofuran (THF).
Last Update：2022-10-16 17:11:31
101831-37-2 - Reference Information
| uses and characteristics | dicezuril is a triazine phenylacetonitrile compound. it is a new type, high-efficiency (only 1 g of the compound is added per ton of feed), low toxicity (no poisoning phenomenon is found in 50 times excess) anticoccidiosis, and is widely used in chicken coccidiosis. In addition, it has preventive and therapeutic effects on a variety of coccidia, and can also be used to prevent ducks, quails, turkeys, geese and rabbits from getting coccidiosis. Dikzhuli is a brand-new synthetic non-ionic portable anticoccidial drug. The anticoccidial index of the six main species of Eimeria in chickens is above 180, which is a high-efficiency anticoccidial drug. It also has the characteristics of low toxicity, broad spectrum, small dosage, wide safety range, no drug withdrawal period, no toxic side effects, no cross-resistance, and no influence of the feed granulation process. This product can be added to the feed for a long time without stopping the drug before slaughter. (does not affect broiler exports); does not affect the growth and development of livestock and poultry. Dikezuli has excellent effects on chicken tenderness, pile type, poison, Brucell, and giant Eimeria. After medication, it can effectively control the occurrence and death of cecal coccidia, and even make The oocysts of diseased chickens disappear. It has good effect on duck coccidia and rabbit coccidia. Clinical trials have shown that the control effect of Diquanil on coccidia is better than other conventionally used anticoccidial drugs and monensin plasma carrier anticoccidial drugs; for fluoropurine (Arprinocid), chloropyridine, and Changshannone, Oxyphenanidine, Monensin-resistant Eimeria tenella, the application of Diquanil is still effective. For example, the concentration of 1 mg/kg feed can effectively control duck coccidiosis, and its effect even exceeds that of polyether antibiotics. 1mg/kg of medicine was fed to rabbits, which was highly effective against liver coccidia and enterococcus in rabbits. Its disadvantage is that long-term medication will appear drug resistance, so it should be used in shuttle or short-term use or alternate with other anticoccidial drugs. | |
| Synthesis and preparation | Using methanol as a solvent, 2, 6-dichloro-α-(4-Chlorophenyl)-4-nitrophenylacetonitrile (A) is hydrogenated and reduced to 4-amino-2 under the catalysis of 5% platinum-carbon, 6-Dichloro-α-(4-chlorophenyl) phenylacetonitrile (B). (B) 2-[[3,5-dichloro -4-[(4-chlorophenyl) cyanomethyl] phenyl]-hydrazinyl]-2-cyanoacetyl urethane (C), (C) 2-[3,5-dichloro -4-[(4-chlorophenyl) cyanomethyl] phenyl]-2,3,4, 5-tetrahydro-3, 5-dicarbonyl -1,2, 4-triazine-6-carboxylic acid (D). Using thioglycolic acid as solvent, (d) decarboxylation reaction at 170 ℃ produces diclazuli. Among them, the operation process of cyclization and hydrolysis is as follows: 7.8 parts of compound (C), 1.98 parts of anhydrous potassium acetate and 120 parts of glacial acetic acid are stirred and refluxed for 3 hours, an appropriate amount of glacial acetic acid and 30 parts of concentrated hydrochloric acid are added, and the stirring and refluxing is continued for 10 hours; Then concentrate, cool and filter, and the filter cake is compound (D). | |
| biological activity | Diclazuril is an anti-coccidial drug. | |
| use | anticoccidial drugs. It has a control effect on a variety of coccidiosis and is used to prevent coccidiosis in chickens, ducks, quails, turkeys, geese and rabbits. Countermeasures to prevent the occurrence of drug resistance: due to the long-term use of an anticoccidial drug, drug resistance will appear. In order to avoid the occurrence of drug resistance, shuttle medication and alternate medication can be used in the prevention plan. Shuttle medication, in the whole feeding cycle, the early use of an anti-coccidial drug, the later use of another anti-coccidial drug. Take turns to use drugs. For chickens raised in a year, one anticoccidial drug is used in the first half of the year, and another anticoccidial drug is used in the second half of the year. The above two medication methods can make the resistance generate electricity or not, and extend the resistance. The service life of coccidial drugs. Anti-coccidiotics. It has a control effect on a variety of coccidiosis and is used to prevent coccidiosis in chickens, ducks, quails, turkeys, geese and rabbits. Countermeasures to prevent the generation of drug resistance: due to the long-term use of an anticoccidial drug, drug resistance will appear. In order to avoid the generation of drug resistance, shuttle medication and alternate medication can be used in the prevention and control plan. Shuttle medicine, chickens raised in a year, use an anti-coccidial medicine in the first half of the year, and use an anti-coccidial medicine in the second half of the year. The above two methods of medicine are used, but the resistance produces electricity or does not produce, which prolongs the anti-coccidial life. |
Last Update：2024-04-09 20:49:11
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