Name | Thienopyridone |
Synonyms | Thienopyridone |
CAS | 1018454-97-1 |
EINECS | 819-423-4 |
Molecular Formula | C13H10N2OS |
Molar Mass | 242.3 |
Storage Condition | -20°C,密封,干燥 |
biological activity | thienoporidone is a potent and selective phosphatase inhibitor of phosphatase of liver regeneration (PRL). For PRL-1, the IC50 values were 173 nM,277 nM and 128 nM PRL-2 and PRL-3, respectively. Thienoporidone has little effect on other phosphatases. Thienoporidone can induce p130Cas lysis and apoptosis, and has anti-cancer effect. |
Target | IC50: 173 nM (PRL-1), 277 nM (PRL-2) and 128 nM (PRL-3) |
Cell Line: | RKO and HT-29 cells HeLa cells |
Concentration: | 0.5 μM, 1.67 μM, 5 μM, 8.33 μM 1 μM, 5 μM, 10 μM, 25 μM, 50 μM, 75 μM |
Incubation Time: | 14 days 24 hours |
Result: | Exhibited a dose-dependent inhibition in cancer cell anchorage-independent growth as measured by either colony number or colony size. A dose-dependent down-regulation of total p130Cas was observed. |