1020149-73-8

Name	SGI-1027
Synonyms	CS-1144 SGI-1027 DNA Methyltransferase Inhibitor II N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide N-[4-[(2-amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)- N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide SGI-1027 SGI-1027 N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
CAS	1020149-73-8

Molecular Formula	C27H23N7O
Molar Mass	461.52
Density	1.387±0.06 g/cm3(Predicted)
Melting Point	>280℃
Solubility	Soluble in DMSO, not in water
Appearance	powder
Color	white to light brown
pKa	13.31±0.70(Predicted)
Storage Condition	2-8°C
Stability	Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Use	SGI-1027, a DNA methyltransferase (DNMT) inhibitor, had IC50 values of 7.5 μM,8 μM and 12.5 μM for DNMT3B,DNMT3A and DNMT1 with poly(dI-dC) as substrate, respectively.
In vitro study	SGI-1027 inhibits DNA methylation by direct inhibition of DNMTs and leads to selective degradation of DNMT1 in various human cancer cell lines. SGI-1027 showed little or no toxic effect in rat hepatoma H4IIE cells. SGI-1027 (0-100 μm) exhibited a modest pro-apoptotic effect in the U937 human leukemia cell line with no associated changes in the cell cycle.

Last Update：2024-01-02 23:10:35

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1020149-73-8

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