1026587-36-9
2-Chloro-6-(difluoromethyl)pyridine
CAS: 1026587-36-9
Molecular Formula: C6H4ClF2N
1026587-36-9 - Names and Identifiers
| Name | 2-Chloro-6-(difluoromethyl)pyridine |
| Synonyms | 2-Chloro-6-(difluoromethyl)pyridine |
| CAS | 1026587-36-9 |
1026587-36-9 - Physico-chemical Properties
| Molecular Formula | C6H4ClF2N |
| Molar Mass | 163.55 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Irritant |
| MDL | MFCD25368743 |
1026587-36-9 - Introduction
2-Chloro-6-(difluoromethyl)pyridine is an organic compound with the chemical formula C6H3ClF2N. It is a colorless to pale yellow solid with a distinctive odor.
The main use of this compound is as a pesticide and pharmaceutical intermediate. It can be used in the synthesis of exuberant insecticides (Picloram) and some antibacterial drugs, antiviral drugs. In addition, it can also be used in reductive decarboxylation reactions and nucleophilic substitution reactions in organic synthesis reactions.
2-Chloro-6-(difluoromethyl)pyridine can be prepared by two main methods. One is through the reaction of hydrogen chloride and ethyl difluoroformate to generate chlorodifluoromethyl compound, and then react with pyridine to obtain the target product. Another method is obtained by reacting p-nitropyridine with chlorocarboxaldehyde and ammonia.
Regarding safety information, 2-Chloro-6-(difluoromethyl)pyridine is an organic compound with certain toxicity and irritation. When operating, it is necessary to wear appropriate protective measures, such as gloves, glasses and protective clothing. Avoid direct contact with skin and eyes, and avoid inhaling its vapors. If it is taken by mistake or inhaled by mistake, it should be treated by medical treatment in time. When stored, it should be placed in a cool, dry and well-ventilated place, away from fire and combustibles.
The main use of this compound is as a pesticide and pharmaceutical intermediate. It can be used in the synthesis of exuberant insecticides (Picloram) and some antibacterial drugs, antiviral drugs. In addition, it can also be used in reductive decarboxylation reactions and nucleophilic substitution reactions in organic synthesis reactions.
2-Chloro-6-(difluoromethyl)pyridine can be prepared by two main methods. One is through the reaction of hydrogen chloride and ethyl difluoroformate to generate chlorodifluoromethyl compound, and then react with pyridine to obtain the target product. Another method is obtained by reacting p-nitropyridine with chlorocarboxaldehyde and ammonia.
Regarding safety information, 2-Chloro-6-(difluoromethyl)pyridine is an organic compound with certain toxicity and irritation. When operating, it is necessary to wear appropriate protective measures, such as gloves, glasses and protective clothing. Avoid direct contact with skin and eyes, and avoid inhaling its vapors. If it is taken by mistake or inhaled by mistake, it should be treated by medical treatment in time. When stored, it should be placed in a cool, dry and well-ventilated place, away from fire and combustibles.
Last Update：2024-04-09 20:52:54
