Molecular Formula | C17H20N6O2S |
Molar Mass | 372.44 |
Density | 1.408±0.06 g/cm3(Predicted) |
Solubility | DMSO: ≥ 45 mg/mL |
pKa | 13.17±0.29(Predicted) |
Storage Condition | -20℃ |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.685 ml | 13.425 ml | 26.85 ml |
5 mM | 0.537 ml | 2.685 ml | 5.37 ml |
10 mM | 0.268 ml | 1.342 ml | 2.685 ml |
5 mM | 0.054 ml | 0.268 ml | 0.537 ml |
biological activity | GNE-493 (compound 5) is an oral dual inhibitor of pan PI3-kinase and mTOR, IC50 values for PI3Kβ, PI3Kδ, PI3Kγ, and mTOR were 3.4 nM, 12 nM, 16 nM, 16 nM, and 32 nM, respectively. |