103858-53-3

103858-53-3 - Names and Identifiers

Name	Ethyl 6-bromoindole-2-carboxylate
Synonyms	6-Br-ICA-OEt 6-BROMO-2-CARBETHOXYINDOLE 6-6-BROMO-2-INDOLECARBOXYLIC Ethyl 6-bromoindole-2-carboxylate ETHYL 6-BROMOINDOLE-2-CARBOXYLATE ethyl 6-bromo-1H-indole-2-carboxylate 6-Bromo-2-Indolecarboxylic Ethyl Ester 6-BROMO-2-INDOLECARBOXYLIC METHYL ESTER 6-6-BROMO-2-INDOLECARBOXYLICMETHYLESTER 6-BROMOINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
CAS	103858-53-3
InChI	InChI=1/C11H10BrNO2/c1-2-15-11(14)10-5-7-3-4-8(12)6-9(7)13-10/h3-6,13H,2H2,1H3

103858-53-3 - Physico-chemical Properties

Molecular Formula	C11H10BrNO2
Molar Mass	268.11
Density	1.554±0.06 g/cm3(Predicted)
Melting Point	178-180 °C
Boling Point	394.7±22.0 °C(Predicted)
Flash Point	192.5°C
Solubility	Soluble in acetone.
Vapor Presure	1.94E-06mmHg at 25°C
Appearance	Crystalline Powder
Color	White
pKa	14.08±0.30(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.646

103858-53-3 - Risk and Safety

Risk Codes	20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	36/37 - Wear suitable protective clothing and gloves.
HS Code	29339900
Hazard Class	IRRITANT

103858-53-3 - Reference Information

application

ethyl 6-bromo-2-indole carboxylate can be used as an intermediate in organic synthesis and pharmaceutical intermediate, mainly used in laboratory research and development and chemical production process.

preparation

80mL of ethanol, 7.2g( 40mmol) 6-bromo -2-indole carboxylic acid were added to a 250mL three-neck bottle, 1.0mL of concentrated sulfuric acid was slowly added dropwise at room temperature, after dropping, the reflux reaction was
30h( TLC tracking). At the end of the reaction, concentrate to 30mL, pour into 60mL of water, extract twice with 20mL of diethyl ether, wash the diethyl ether layer with 5% sodium carbonate solution
once, then wash with water until neutral, dry with anhydrous magnesium sulfate, evaporate the diethyl ether to obtain 7.7g of yellow to brown powder 6-bromo -2-indole carboxylate with 92.3% yield.

Last Update：2024-04-09 18:58:34