1048970-17-7

1048970-17-7 - Names and Identifiers

Name	tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidine-1-carboxylate
Synonyms	N-Boc-piperidine-4-boronic acid pinacol ester 1-BOC-PIPERIDINE-4-BORONIC ACID PINACOL ESTER 1-Boc-piperidin-4-ylboronic acid pinacol ester TERT-BUTOXYCARBONYLPIPERIDINE-4-BORONIC ACID, PINACOL ESTER Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidin-1-carboxylate tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidine-1-carboxylate 1-Piperidinecarboxylic acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester 1-(tert-Butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidine, tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidine-1-carboxylate
CAS	1048970-17-7
InChIKey	IBLQMWKHENBVJE-UHFFFAOYSA-N

1048970-17-7 - Physico-chemical Properties

Molecular Formula	C16H30BNO4
Molar Mass	311.22
Density	1.03
Melting Point	60-65°C
Boling Point	358.8±35.0 °C(Predicted)
pKa	-1.07±0.40(Predicted)
Storage Condition	2-8°C
Use	Use 1-n-tert-butoxycarbonylpiperidine-4-boronic acid cyanohydrin Ester is a carboxylic acid ester derivative, which can be used as an intermediate in organic synthesis.

1048970-17-7 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3

1048970-17-7 - Upstream Downstream Industry

Raw Materials

1-Boc-piperidine
PIPERIDINE-4-BORONIC ACID
4-Pyridineboronic acid pinacol ester
N-BOC-piperidine-4-carboxylic acid
2,2'-Bis-1,3,2-benzodioxaborole
TETRAHYDROXYDIBORON
1-N-BOC-4-BROMOPIPERIDINE
Di-tert-butyl dicarbonate
CATECHOLBORANE
Pinacol

1048970-17-7 - Uses and synthesis methods

introduction

1-N-tert-butoxycarbonylpiperidine-4-borate pinacol ester is an alkyl borate compound. Alkyl borate compounds are a kind of important organic synthesis intermediates, which can be cross-coupled with electrophiles to prepare drug molecules and play an important role in pharmaceutical chemistry applications.

Preparation

under the protection of argon gas, 0.25mmol of 4-bromopiperidine -1-carboxylic acid tert-butyl ester and 0.375mmol of double neopentyl glycol borate were mixed with 0.5ml of acetonitrile, 0.025mmolCuI, 0.5mmol of lithium methoxide and 0.025mmol of triphenylphosphine were added, stirred and reacted at 37 ℃ for 24 hours, and the reaction was purified to obtain 1-N-tert-butox.

Last Update：2024-04-09 21:01:54