1049730-40-6

1049730-40-6 - Names and Identifiers

Name	1-(2,2-difluoroethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Synonyms	1-(2,2-Difluoroethyl)pyrazole-4-boronic Acid Pinacol Ester (1-(2,2-DIFLUOROETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER 1-(2,2-difluoroethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-(2,2-difluoroethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1H-Pyrazole, 1-(2,2-difluoroethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CAS	1049730-40-6

1049730-40-6 - Physico-chemical Properties

Molecular Formula	C11H17BF2N2O2
Molar Mass	258.0726864
Density	1.17±0.1 g/cm3(Predicted)
Boling Point	333.0±42.0 °C(Predicted)
pKa	1.45±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

1049730-40-6 - Upstream Downstream Industry

Raw Materials

2-IODO-1,1-DIFLUOROETHANE
2,2-DIFLUOROETHYL TRIFLUOROMETHANESULFONATE
1-Methyl-4-pyrazole boronic acid pinacol ester
4-Pyrazoleboronic acid pinacol ester

1049730-40-6 - Introduction

1-(2,2-difluoroethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is an organic compound with the chemical formula C13H18BF2N3O2.

The compound has the following properties:
-Appearance: colorless crystal or powder solid;
-Melting Point: about 68-70 ℃;
-Solubility: Slightly soluble in some organic solvents, such as ethanol, dimethylformamide and dichloromethane, but almost insoluble in water;
-Stability: Stable under regular conditions, but avoid contact with strong oxidants and strong acids.

The main uses of 1-(2,2-difluoroethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole include:
-as reagents and intermediates in organic synthesis;
-for pharmaceutical research and pesticide synthesis;
-For the preparation of organic photoelectric materials and functional molecules.

The method of preparing 1-(2,2-difluoroethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is generally through the following steps:
1. Reaction of 4-(chloromethyl)-1,3, 2-dioxaborolane with 1-(2,2-difluoroethyl)-1H-pyrazole, formation of 1-(2,2-difluoroethyl)-4-(chloromethyl)-1H-pyrazole;
2. Reaction with tetramethylstannous (IV) fluoride in the presence of a base and tetramethylbenzyl diphosphate gives 1-(2,2-difluoroethyl)-4-(tetramethyl -1,3, 2-dioxaborol-pentan-2-yl)-1H-pyrazole;
3.1-(2,2-difluoroethyl)-4-(tetramethyl -1,3, 2-dioxaborentan-2-yl) the-LH-pyrazole is reacted with a boronic acid or Boronic ester to give the desired product.

For safety information on this compound, consult the supplier or refer to the relevant chemical literature. During handling and handling, the laboratory's safe practices should be observed, including wearing appropriate personal protective equipment (such as gloves, glasses, laboratory coats, etc.), avoiding inhalation, contact with skin and eyes, make sure to do it with good ventilation.

Last Update：2024-04-09 19:05:54