1051387-90-6
SPI 112
CAS: 1051387-90-6
Molecular Formula: C22H17FN4O5S
1051387-90-6 - Names and Identifiers
1051387-90-6 - Physico-chemical Properties
| Molecular Formula | C22H17FN4O5S |
| Molar Mass | 468.46 |
| Density | 1.52±0.1 g/cm3(Predicted) |
| Melting Point | >300 °C |
| Solubility | Soluble in DMSO |
| pKa | 4.15±0.10(Predicted) |
| Storage Condition | -20℃ |
| Use | SPI 112 is a cell-impermeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2) with IC50 of 1 µM in cell-free assays. |
| In vitro study | SPI-112 has a polar -NO 2 or a negatively charged -COOH group and has no detectable cellular activity, suggesting that SPI-112 is not cell permeable. In surface plasmon resonance (SPR) binding assay, SPI-112 displays a 1:1 stoichiometric binding kinetics to SHP2 with a kinetic constant K D of 1.30 µM. Enzyme kinetic data obtained with SPI-112 are best fitted with the competitive inhibition model (K i of 0.8 µM), suggesting that SPI-112 interacts with the catalytic site of SHP2. |
1051387-90-6 - Reference
| Reference Show more | 1: Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.Chen L, Pernazza D, Scott LM, Lawrence HR, Ren Y, Luo Y, Wu X, Sung SS, Guida WC, Sebti SM, Lawrence NJ, Wu J. Biochem Pharmacol. 2010 Sep 15;80(6):801-10. doi: 10.1016/j.bcp.2010.05.019. Epub 2010 May 25.PMID: 20510203 Free PMC ArticleSimilar articles |
1051387-90-6 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.135 ml | 10.673 ml | 21.347 ml |
| 5 mM | 0.427 ml | 2.135 ml | 4.269 ml |
| 10 mM | 0.213 ml | 1.067 ml | 2.135 ml |
| 5 mM | 0.043 ml | 0.213 ml | 0.427 ml |
Last Update：2024-01-02 23:10:35
1051387-90-6 - Reference Information
| biological activity | SPI-112 is a potent, selective and competitive inhibitor of SHP2 (PTPN11), the IC50 of protein tyrosine phosphatase (PTP) and PTP1B were 1 μm, 18.3 μm and 14.5 μm, respectively. |
| Target | IC50: 1 μm (SHP2), 18.3 μm (PTP) and 14.5 μm (PTP1B) |
Last Update：2024-04-10 22:29:15
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Product Name: SPI 112 Visit Supplier Webpage Request for quotationCAS: 1051387-90-6
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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