1056024-94-2
Azido-dPEG4-acid
CAS: 1056024-94-2
Molecular Formula: C9H17N3O5
1056024-94-2 - Names and Identifiers
1056024-94-2 - Physico-chemical Properties
| Molecular Formula | C9H17N3O5 |
| Molar Mass | 247.25 |
| Storage Condition | Room Temprature |
| In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
1056024-94-2 - Reference Information
| biological activity | N3-PEG3-CH2CH2COOH is a PEG-based PROTAC linker that can be used to synthesize BI-3663 (HY-111546), BI-4216 and BI-0319. N3-PEG3-CH2CH2COOH is also a non-cleavable ADC linker with 3-unit PEG, which can be used to synthesize antibody-coupled drugs (ADC). |
| target | PEGs Non-cleavable |
| in vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
Last Update：2024-04-10 22:29:15
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