1062648-63-8
DMT1 blocker 2
CAS: 1062648-63-8
Molecular Formula: C16H13N3O
1062648-63-8 - Names and Identifiers
| Name | DMT1 blocker 2 |
| Synonyms | DMT1 blocker 2 |
| CAS | 1062648-63-8 |
1062648-63-8 - Physico-chemical Properties
| Molecular Formula | C16H13N3O |
| Molar Mass | 263.29 |
| Appearance | Solid |
| Storage Condition | 2-8°C，密封，干燥 |
| In vitro study | DMT1 blocker 2 (Compound 12f) (10 μM; 24 h) has no cytotoxic to HepG2 cells. DMT1 blocker 2 (10 μM) inhibits 44% of CYP3A4 activity. |
| In vivo study | DMT1 blocker 2 (50 mg/kg; p.o.) blocks iron uptake by enterocytes in an acute rat model of iron hyperabsorption. Animal Model: Weanling (3-4 weeks) rats were placed on a low iron diet for four weeks Dosage: 50 mg/kg Administration: Oral gavage followed 1 h later by an iron challenge Result: Attenuated the post-challenge serum iron increase. |
