106876-54-4

106876-54-4 - Names and Identifiers

Name	4-Amino-2,2-difluoro-1,3-benzodioxole
Synonyms	4-AMINO-2,2-DIFLUOROBENZODIOXOLE 2,2-DIFLUORO-4-AMINOBENZODIOXOLE 2,2-difluoro-1,3-benzodioxol-4-amine 4-AMINO-2,2-DIFLUORO-1,3-BENZODIOXOLE 4-Amino-2,2-difluoro-1,3-benzodioxole 2,2-DIFLUORO-4-AMINO-1,3-BENZODIOXOLE [2,4-dichloro-6-(trifluoromethyl)phenyl]hydrazine 2,2-Difluoro-1,3-benzodioxol-4-amine, 2,3-(Difluoromethylenedioxy)aniline
CAS	106876-54-4
InChI	InChI=1/C7H5F2NO2/c8-7(9)11-5-3-1-2-4(10)6(5)12-7/h1-3H,10H2

106876-54-4 - Physico-chemical Properties

Molecular Formula	C7H5F2NO2
Molar Mass	173.12
Density	1.51±0.1 g/cm3(Predicted)
Boling Point	201.0±40.0 °C(Predicted)
Flash Point	75.4°C
Water Solubility	Not miscible or difficult to mix in water.
Vapor Presure	0.315mmHg at 25°C
pKa	3.26±0.40(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.556

106876-54-4 - Risk and Safety

Hazard Symbols	T - Toxic
Risk Codes	R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	2810
Hazard Note	Toxic
Hazard Class	6.1
Packing Group	III

106876-54-4 - Introduction

4-amino -2, 2-difluoro-1, 3-benzodioxene (abbreviated as ADF) is an organic compound with the chemical formula C12H6F2N2. ADF is a yellow crystalline solid with a high melting and boiling point. Its solubility is poor, insoluble in water but soluble in most organic solvents.

ADF has many important applications. First, ADF is an important dye intermediate, which can be used to synthesize various organic dyes. Secondly, ADF can also be used as a fluorescent marker, which is widely used in biomedical and optoelectronic fields. In addition, ADF can also be used as a catalyst and a reducing agent in organic synthesis reactions.

There are two main methods of preparing ADF. One is obtained by reacting p-phenylenediamine with 2,2-difluoroacetyl chloride through a fluorination reaction. The other is obtained by reacting 4-amino -1, 3-benzodioxane with a fluorinating reagent such as hydrogen fluoride hydrofluoric acid. The process of preparing ADF needs to be carried out under inert gas, taking care to prevent the intermediate from being exposed to air and moisture.

Regarding the safety information of ADF, it is a low-toxic compound, but it is still necessary to pay attention to safe operation. Wear protective gloves and glasses when exposed to ADF to prevent the compound from causing irritation to the skin and eyes. Good ventilation should be maintained during operation to avoid inhalation of dust and vapor. When storing ADF, keep it in a sealed container away from fire and oxidizing agents.

In summary, 4-amino -2, 2-difluoro-1, 3-benzodioxene is an organic compound with a variety of applications such as dye intermediates, fluorescent markers, and catalysts. Its preparation method mainly has two kinds of fluorination reaction and reaction with fluorination reagent. Pay attention to safety during operation and storage, avoid contact with skin and glasses, and maintain good ventilation conditions.

Last Update：2024-04-10 22:29:15