1072951-50-8

1072951-50-8 - Names and Identifiers

Name	2-Hydroxy-4-trifluoromethylphenylboronic acid
Synonyms	[2-hydroxy-4-(trifluoromethyl)phenyl]boron 2-Hydroxy-4-trifluoromethylphenylboronic acid 2-Hydroxy-4-(trifluoromethyl)phenylboronic acid Boronic acid, B-[2-hydroxy-4-(trifluoromethyl)phenyl]-
CAS	1072951-50-8

1072951-50-8 - Physico-chemical Properties

Molecular Formula	C7H6BF3O3
Molar Mass	205.93
Density	1.50±0.1 g/cm3(Predicted)
Boling Point	317.2±52.0 °C(Predicted)
pKa	7.90±0.58(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

1072951-50-8 - Reference Information

Uses

2-hydroxy-4-trifluoromethylphenylboronic acid is an organic intermediate, and alkyl boronic acid compounds are a class of important organic synthesis intermediates. It can be cross-coupled with electrophiles to prepare drug molecules and play an important role in medicinal chemistry applications.

Application Example

2-hydroxy-4-trifluoromethylphenylboronic acid can be used to prepare compounds having the following structure for the treatment and/or prevention of neurodegenerative diseases (e. g., neurodegeneration in prion diseases (priondisease)). These compounds are used to treat diseases, conditions or disorders that are at least partially mediated by eukaryotic initiation factor 2B, such as Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and frontotemporal dementia (FTD) and other neurodegenerative diseases have a negative impact on the lives of millions of people.

Last Update：2024-04-10 22:29:15