Use | (ethyl 2-oxime-cyanoacetate)-N,N-dimethyl-morpholino urea hexafluorophosphate, also known as COMU, is a polypeptide condensation reagent, which is mainly used in the synthesis of polypeptide drug molecules and is widely used in solid phase and liquid phase. compared with the traditional first-generation condensation reagents (carbodiimides) represented by DCC and the second-generation condensation reagents (onium salts) represented by HATU, COMU has better solubility, stability, reactivity, low risk and low sensitivity to the human body; At the same time, the by-products generated are easily soluble in water and can be removed well, so the synthesis of COMU polypeptide drug molecules, especially in the solid phase synthesis of more obvious advantages. |