1076197-05-1
4-(4-Bromophenyl)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinecarboxylic acid
CAS: 1076197-05-1
Molecular Formula: C17H22BrNO4
1076197-05-1 - Names and Identifiers
1076197-05-1 - Physico-chemical Properties
| Molecular Formula | C17H22BrNO4 |
| Molar Mass | 384.26 |
| Density | 1.393±0.06 g/cm3(Predicted) |
| Boling Point | 484.4±45.0 °C(Predicted) |
| pKa | 3.96±0.20(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD11226814 |
1076197-05-1 - Introduction
1-Boc-4-(4-bromophenyl)-4-piperidinecarboxylic acid is an organic compound with the following properties:
1. Appearance: White crystalline solid.
2. molecular formula: C16H18BrNO4.
3. Molecular weight: 370.22g/mol.
4. Solubility: Soluble in organic solvents such as methanol, ethanol and dimethylformamide, almost insoluble in water.
Its main uses are:
1. As a protecting group in organic synthesis: Boc protecting group can protect the amine group to prevent unnecessary side reactions in the reaction.
2. For the preparation of pharmaceutical intermediates: The compound can be used to synthesize various drugs, such as anti-tumor drugs.
Preparation Method:
1-Boc-4-(4-bromophenyl)-4-piperidinecarboxylic acid can be synthesized by the following steps:
1. First, 4-bromobenzyl alcohol and ethyl N,N-dimethylcarbamate were reacted to obtain 4-(4-bromophenyl)-4-piperidinemethanol.
2. Next, 4-(4-bromophenyl)-4-piperidinemethanol and ethyl N-butyldimethylcarbamate were reacted to obtain 1-Boc-4-(4-bromophenyl)-4-piperidinecarboxylic acid.
Safety Information:
1-Boc-4-(4-bromophenyl)-4-piperidinecarboxylic acid is an organic compound and requires the following safety precautions:
1. Avoid contact with skin and eyes to avoid irritation and damage.
2. During operation, ensure good ventilation conditions.
3. avoid inhalation of its dust or steam.
4. use to wear appropriate personal protective equipment, such as gloves and protective glasses.
5. Waste must be disposed of in accordance with local regulations.
1. Appearance: White crystalline solid.
2. molecular formula: C16H18BrNO4.
3. Molecular weight: 370.22g/mol.
4. Solubility: Soluble in organic solvents such as methanol, ethanol and dimethylformamide, almost insoluble in water.
Its main uses are:
1. As a protecting group in organic synthesis: Boc protecting group can protect the amine group to prevent unnecessary side reactions in the reaction.
2. For the preparation of pharmaceutical intermediates: The compound can be used to synthesize various drugs, such as anti-tumor drugs.
Preparation Method:
1-Boc-4-(4-bromophenyl)-4-piperidinecarboxylic acid can be synthesized by the following steps:
1. First, 4-bromobenzyl alcohol and ethyl N,N-dimethylcarbamate were reacted to obtain 4-(4-bromophenyl)-4-piperidinemethanol.
2. Next, 4-(4-bromophenyl)-4-piperidinemethanol and ethyl N-butyldimethylcarbamate were reacted to obtain 1-Boc-4-(4-bromophenyl)-4-piperidinecarboxylic acid.
Safety Information:
1-Boc-4-(4-bromophenyl)-4-piperidinecarboxylic acid is an organic compound and requires the following safety precautions:
1. Avoid contact with skin and eyes to avoid irritation and damage.
2. During operation, ensure good ventilation conditions.
3. avoid inhalation of its dust or steam.
4. use to wear appropriate personal protective equipment, such as gloves and protective glasses.
5. Waste must be disposed of in accordance with local regulations.
Last Update：2024-04-09 21:21:28
