107910-75-8
Ganciclovir sodium
CAS: 107910-75-8
Molecular Formula: C9H12N5NaO4
107910-75-8 - Names and Identifiers
| Name | Ganciclovir sodium |
| Synonyms | Unii-02L083W284 Rs 21592 sodium Ganciclovir sodium GANCICLOVIR SODIUM Ganciclovir monosodium salt 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-3,9-dihydro-6H-purin-6-one sodium 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-3H-purin-6-olate 2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6h-purin-6-one sodium salt 6H-Purin-6-one, 1,9-dihydro-2-amino-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, monosodium salt 6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, monosodium salt |
| CAS | 107910-75-8 |
| EINECS | 641-368-8 |
| InChI | InChI=1/C9H14N5O4.Na/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16;/h3,5,8,15-16H,1-2,4H2,(H3,10,12,13);/q-1;+1 |
107910-75-8 - Physico-chemical Properties
| Molecular Formula | C9H12N5NaO4 |
| Molar Mass | 277.21 |
| Storage Condition | 2-8℃ |
| In vitro study | Ganciclovir sodium is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 mumol versus 72 mumol for acyclovir.The primary mechanism of ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase. Ganciclovir sodium is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase. |
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