108-41-8

108-41-8 - Names and Identifiers

Name	3-Chlorotoluene
Synonyms	MCT 3-Chlorotoluene 3-CHLOROTOLUENE M-CHLOROTOLUENE m-tolyl chloride M-chloro toluene CHLOROTOLUENE (3-) META CHLORO TOLUENE 1-chloro-3-methylbenzene 1-CHLORO-3-METHYLBENZENE 3-CHLORO-1-METHYLBENZENE 1-chloro-3-methyl-benzen
CAS	108-41-8
EINECS	203-580-5
InChI	InChI=1/C7H7Cl/c1-6-3-2-4-7(8)5-6/h2-5H,1H3

108-41-8 - Physico-chemical Properties

Molecular Formula	C7H7Cl
Molar Mass	126.58
Density	1.072 g/mL at 25 °C (lit.)
Melting Point	-48 °C (lit.)
Boling Point	160-162 °C (lit.)
Flash Point	123°F
Water Solubility	slightly soluble
Solubility	0.04g/l
Vapor Presure	3.6 mbar @ 20 C
Appearance	Liquid
Color	Clear colorless to slightly yellow
Merck	14,2171
BRN	1903632
Storage Condition	0-6°C
Stability	Stable. Flammable. Incompatible with strong oxidizing agents.
Explosive Limit	1.3-8.3%(V)
Refractive Index	n20/D 1.522(lit.)
Physical and Chemical Properties	Character: colorless liquid. melting point -48 ℃ boiling point 161.2 ℃ relative density 1.0722 refractive index 1.5214 flash point 50 ℃ solubility insoluble in water, soluble in benzene, ethanol, ether and chloroform.
Use	Used as a pharmaceutical Intermediate

108-41-8 - Risk and Safety

Risk Codes	R20 - Harmful by inhalation R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description	S24/25 - Avoid contact with skin and eyes. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 2238 3/PG 3
WGK Germany	2
RTECS	XS8990000
TSCA	Yes
HS Code	29039990
Hazard Class	3
Packing Group	III

108-41-8 - Nature

Open Data Verified Data

colorless liquid, boiling point 161.2 °c. Melting Point -48 °c. The relative density was 1. 0722. Flash point 50 °c. Ignition point> 500 °c. Refractive index 5214. The vapor pressure was 1333 (43.2 °c). Insoluble in water, soluble in benzene, ethanol, ether and chloroform.

Last Update：2024-01-02 23:10:35

108-41-8 - Preparation Method

Open Data Verified Data

with M-aminotoluene as raw material, by diazotization, chlorine obtained. M-toluidine was added to water, and concentrated hydrochloric acid and an aqueous solution of sodium nitrite were added for diazotization reaction. Then, diazo liquid was added to cuprous chloride for chlorination reaction, and the product was obtained by distillation.

Last Update：2022-01-01 10:40:58

108-41-8 - Use

Open Data Verified Data

organic synthesis intermediates, solvent.

Last Update：2022-01-01 10:40:56

108-41-8 - Safety

Open Data Verified Data

This product is toxic, rat LD50 3600mg/kg. The operating site should be well ventilated, the equipment should be sealed, and the operator should wear protective equipment.
This product can be burned in case of open flame, should be stored in a cool, ventilated warehouse, away from the fire, heat source, and the oxidant is stored separately, light and light when handling, keep the package intact.

Last Update：2022-01-01 10:40:59

108-41-8 - Reference Information

NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Application	It is an important organic intermediate, which is widely used in pharmaceutical and pesticide industries, it is also a good organic solvent. P-chlorotoluene is an important fine chemical raw material, and p-chlorotoluene with a purity of more than 95% is used to synthesize pesticides with high efficiency, low toxicity and broad spectrum, such as carbendazim, etc. The market demand is strong.
toxicity	respiratory or skin allergy: may be harmful by skin absorption, may cause skin irritation. None of the components in this product at levels greater than or equal to 0.1% were identified by IARC as a possible or positive human carcinogen.
Use	used as a pharmaceutical intermediate used in organic synthesis, solvent.
production method	is obtained by diazotization and substitution of M-aminotoluene. M-aminotoluene was added to water, concentrated hydrochloric acid was slowly added, and sodium nitrite solution was added dropwise at 0-5 °c. The diazo solution is then added to cuprous chloride for a displacement reaction. The resulting crude product is distilled to obtain a finished product. If the diazonium salt is prepared as the zinc chloride double salt of M-toluidine diazonium salt, it is decomposed under reflux in diethyl ether and the reaction is cooled, washed with water and dried. After the ether was recovered, the mixture was subjected to atmospheric distillation, and the fraction of 160-162 ° C. Was collected to obtain m-chlorotoluene. The advantage of this method is that the diazonium salt is not easily hydrolyzed to produce phenols.