108-45-2
m-Phenylenediamine
CAS: 108-45-2
Molecular Formula: C6H8N2
108-45-2 - Names and Identifiers
| Name | m-Phenylenediamine |
| Synonyms | mPDA benzenediamine diaminobenzene meta-aminoaniline C.I. Developer 11 1,3-Diaminobenzene 1,3-Benzenediamine m-Phenylenediamine benzene-1,3-diamine 1,3-Diamino benzene m-Phenylene Diamine 1,3-Phenylenediamine Metaphenylene Diamine Meta Phenylenediamine Meta-Phenylenediamine 1,3-Benzenediamine(9CI) meta-Phenylenediamine (MPD) META PHENYLENE DIAMINE - FLAKE |
| CAS | 108-45-2 |
| EINECS | 203-584-7 |
| InChI | InChI=1/C6H8N2/c7-5-2-1-3-6(8)4-5/h1-4H,7-8H2 |
| InChIKey | WZCQRUWWHSTZEM-UHFFFAOYSA-N |
108-45-2 - Physico-chemical Properties
| Molecular Formula | C6H8N2 |
| Molar Mass | 108.14 |
| Density | 1,139 g/cm3 |
| Melting Point | 64-66 °C |
| Boling Point | 282-284 °C |
| Flash Point | >230°F |
| Water Solubility | 350 g/L (25 ºC) |
| Solubility | 350g/l |
| Vapor Presure | 0.62 mm Hg ( 100 °C) |
| Vapor Density | 3.7 (vs air) |
| Appearance | pellets |
| Color | Yellow to light tan or brown gray |
| Exposure Limit | ACGIH: TWA 0.1 mg/m3 |
| Merck | 14,7283 |
| BRN | 471357 |
| pKa | 5.11, 2.50(at 20℃) |
| PH | 8 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Sensitive | Air Sensitive |
| Refractive Index | 1.6339 |
| Physical and Chemical Properties | Appearance: colorless needle-like crystals, unstable in the air, easy to become light red Melting Point: 63-65 Boiling Point: 282-284 flash point: 175 specific gravity (25°C) 1.0696 refractive index: 1.6339 water-soluble: soluble in water (350g/L at 25), soluble in ethanol, water, chloroform, acetone, dimethylformamide, slightly soluble in ether, carbon tetrachloride, insoluble in benzene, toluene, butanol |
| Use | Intermediates of azo dyes and azine dyes, mainly used in the manufacture of direct tanning RN, basic Orange, basic Brown G, direct tanning G and other dyes, and used as fur dyes in Japan, the consumption of azo dyes accounted for 90% of the total consumption of M-phenylenediamine. It is also used as a curing agent for epoxy resin, a coagulant for cement, and for dyeing water, mordant, chromogenic agent, etc. |
108-45-2 - Risk and Safety
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36 - Irritating to the eyes R43 - May cause sensitization by skin contact R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R68 - Possible risk of irreversible effects R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S28A - |
| UN IDs | UN 1673 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | SS7700000 |
| FLUKA BRAND F CODES | 8-10-23 |
| TSCA | Yes |
| HS Code | 29215119 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 in rats (mg/kg): 650 orally; 283 i.p. (Burnett) |
108-45-2 - Upstream Downstream Industry
| Downstream Products | 1,3-Difluorobenzene |
108-45-2 - Nature
Open Data Verified Data
colorless needle-like crystals. Unstable in air, usually in the form of a stable hydrochloride. The relative density was 1.0696. The melting point of 63~64 deg C, boiling point of 282~284 deg C. Refractive index 6339. Soluble in water, ether and ethanol.
Last Update：2024-01-02 23:10:35
108-45-2 - Preparation Method
Open Data Verified Data
nitrobenzene is nitrated into a mixture of M-, o-and p-dinitrobenzene by mixed acid, refined by sodium sulfite and liquid alkali to obtain m-dinitrobenzene, and then reduced by iron powder to obtain m-phenylenediamine.
Last Update：2022-01-01 10:52:03
108-45-2 - Use
Open Data Verified Data
azo dyes and azine dye intermediates, mainly used in the manufacture of direct tanning RN, and used as fur dyes. It is also used as a curing agent for epoxy resin and an accelerator for cement.
Last Update：2022-01-01 10:52:03
108-45-2 - Safety
Open Data Verified Data
- toxic. Its toxicity and protection method see O-phenylenediamine. Rats were injected subcutaneously with MLD 600mg/kg.
- packaged in iron drum, 50kg per barrel. Storage should be moisture-proof, sunscreen. To prevent oxidation, an appropriate amount of a reducing agent was added. Hazardous materials shall be stored and transported according to regulations.
Last Update：2022-01-01 10:52:04
108-45-2 - Reference Information
| LogP | -0.39 at 20℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| (IARC) carcinogen classification | 3 (Vol. 16, Sup 7) 1987 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| application | mainly used as dye intermediate and epoxy resin curing agent azo dye and azazine dye intermediate, mainly used to manufacture direct sun-resistant RN, basic orange, basic brown G, direct sun-resistant G and other dyes, and used as fur dye. in Japan, isophenylenediamine consumed by azo dye accounts for 90% of the total consumption. It is also used as a curing agent for epoxy resin, a coagulant for cement, and for dyeing water, mordant, developer, etc. used as analytical reagent, resin curing agent and polymerization inhibitor, also used in the synthesis of dyes spectrophotometric determination of nitrite, bromate, bromide, chromate, ozone, gold, copper, dichromate, iron, oxygen and platinum, determination of active chlorine, chromium, iridium, nitrite and palladium. |
| Production method | Nitrobenzene is nitrated with mixed acid into a mixture of m-, o-and p-dinitrobenzene, and then refined with sodium sulfite and liquid alkali to obtain m-dinitrobenzene, and then reduced or hydrogenated with iron powder to obtain m-phenylenediamine. Raw material consumption quota: nitrobenzene 1400kg/t, nitric acid 787kg/t, sulfuric acid (98%)780kg/t, iron powder 3083kg/t. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50: 280 mg/kg; Oral-mouse LD50: 67.7 mg/kg |
| flammability hazard characteristics | open flame is combustible; heating emits toxic aniline gas |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation |
| fire extinguishing agent | mist water, carbon dioxide, sand |
| occupational standard | TWA 0.1 mg/m3 |
| spontaneous combustion temperature | 560°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:54:55
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