1081-04-5

1081-04-5 - Names and Identifiers

Name	5-Bromo-1H-Indazole-3-Carboxylic Acid Ethyl Ester
Synonyms	ethyl 5-broMo-1H-indazol-3-carboxylate Ethyl 5-Bromo-1H-Indazole-3-Carboxylate ETHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE 5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTE 5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 5-Bromo-1H-Indazole-3-Carboxylic Acid Ethyl Ester 1H-Indazole-3-carboxylic acid, 5-broMo-, ethyl ester
CAS	1081-04-5
InChI	InChI=1/C10H9BrN2O2/c1-2-15-10(14)9-7-5-6(11)3-4-8(7)12-13-9/h3-5H,2H2,1H3,(H,12,13)

1081-04-5 - Physico-chemical Properties

Molecular Formula	C10H9BrN2O2
Molar Mass	269.09
Density	1.624±0.06 g/cm3(Predicted)
Melting Point	142 °C
Boling Point	406.4±25.0 °C(Predicted)
Flash Point	199.6°C
Vapor Presure	8.15E-07mmHg at 25°C
pKa	10.67±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.653

1081-04-5 - Introduction

5-bromo -1H-indazole -3-carboxylic acid ethyl ester, chemical formula is C10H8BrNO2, is an organic compound.

Nature:
Ethyl 5-bromo-1H-indazole-3-carboxylate is a colorless to pale yellow liquid. It has a low boiling point and flash point and is soluble in organic solvents such as ether and chloroform. It has a ring structure similar to pyrrole and thiazole, containing bromine and ethyl formate groups.

Use:
This compound is useful as an intermediate in organic synthesis. It can be used to prepare indole and indole derivatives such as oxamine and indole-3-carboxylic acid. In addition, it can also be used in the synthesis of certain pharmaceuticals, pesticides and dyes.

Preparation Method:
The preparation of ethyl 5-bromo-1H-indazole-3-carboxylate is usually achieved by bromination reaction of indazole. Specifically, a common preparation method is to react indazole with sodium hypobromite or stannous bromide to form 5-bromo-1H-indazole, which is then acidified with glycolic acid to form the desired product.

Safety Information:
Ethyl 5-bromo-1H-indazole-3-carboxylate is a chemical that should be handled with care. It may be irritating to the eyes, skin and respiratory system, so wear appropriate protective equipment when using it. At the same time, it should be operated in a well-ventilated environment and avoid direct contact with skin. In case of skin contact or inhalation, rinse immediately with water and seek medical help.

Last Update：2024-04-09 20:49:11