108605-62-5
A77 1726
CAS: 108605-62-5;163451-81-8
Molecular Formula: C12H9F3N2O2
108605-62-5 - Names and Identifiers
108605-62-5 - Physico-chemical Properties
| Molecular Formula | C12H9F3N2O2 |
| Molar Mass | 270.21 |
| Density | 1.424±0.06 g/cm3(Predicted) |
| Melting Point | 229-232°C |
| Boling Point | 410.8±45.0 °C(Predicted) |
| Flash Point | 173.3°C |
| Solubility | Soluble in DMSO (32 mg/ml at 25 °C), methanol, DMF (~21.6 mg/ml), ethanol (1.35 mg/ml |
| Vapor Presure | 6.63E-06mmHg at 25°C |
| Appearance | neat |
| Color | White |
| pKa | 5.20±0.50(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Refractive Index | 1.551 |
| In vitro study | Terifluomide primary is used as an inhibitor of dihydrowhey dehydrogenase (DHODH), a key mitochondrial enzyme involved in the de novo synthesis of pyrimidine in fast-proliferating cells. By reducing the activity of T and B lymphocytes with a high degree of proliferative activity, teriflunoride may attenuate the inflammatory response to autoantigens in MS. Thus, for white blood cells, Teri flunamide can be considered a cytostatic agent rather than a cytotoxic drug. teriflunamide primary is used as an inhibitor of dihydrowhey dehydrogenase (DHODH), a key mitochondrial enzyme that participates in the de novo synthesis of pyrimidines in fast-proliferating cells. By reducing the activity of T and B lymphocytes with a high degree of proliferative activity, teriflunoride may attenuate the inflammatory response to autoantigens in MS. Thus, for white blood cells, Teri flunamide can be considered a cytostatic agent rather than a cytotoxic drug. |
| In vivo study | Teri flunoride has been shown to have beneficial effects in two independent animal models of demyelinating disease. In the Black Thorn mouse model of experimental autoimmune encephalitis (EAE), the administration of teriflunamide has demonstrated its effectiveness as both a prophylactic and a therapeutic agent in the clinic, histopathology and electrophysiology. Also, in the female Lewis rat model of EAE, administration of teriflunamide resulted in beneficial prophylactic and clinical therapeutic effects that delayed the onset of disease and attenuated severity. Teri flunamide has demonstrated beneficial effects in two independent animal models of demyelinating disease. In the Black Thorn mouse model of experimental autoimmune encephalitis (EAE), the administration of teriflunamide has demonstrated its effectiveness as both a prophylactic and a therapeutic agent in the clinic, histopathology and electrophysiology. Also, in the female Lewis rat model of EAE, administration of teriflunamide resulted in beneficial prophylactic and clinical therapeutic effects that delayed the onset of disease and attenuated severity. |
108605-62-5 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| HS Code | 2926900005 |
108605-62-5 - Introduction
A77 1726 is an organic compound with the chemical formula C3H4F4O, which has the following properties:
1. Physical properties: A77 1726 is a colorless liquid with a special pungent smell. It is less dense, with a melting point of -42 ° C and a boiling point of 79 ° C.
2. Chemical properties: A77 1726 is a highly reactive compound that can react with water and moisture in the air to generate strong hydrofluoric acid, so it should be handled in a dry environment. It can be used as a strong fluorination reagent for fluorination reactions in organic synthesis.
The main uses of A77 1726 include:
1. Organic Synthesis: as a fluorination reagent, A77 1726 can fluorinate the hydrogen atoms in organic matter to generate fluorinated compounds, which are widely used in the fields of medicine, pesticide and material science.
2. Surface treatment: A77 1726 can be used to fluorinate the surface of metal, plastic, glass and other materials to improve the wear resistance, temperature resistance and corrosion resistance of the surface.
A77 1726 can be prepared by the following steps:
1. Reacting fluoroacetyl fluoride (CF3COF) with hydrofluoric acid to produce fluoroacetyl fluoramide (CF3CONH2).
2. The A77 1726 is obtained by dehydration reaction of fluoroacetylfluoramine.
A77 1726 safety information is as follows:
1. Toxicity: A77 1726 has a certain toxicity, the skin and eyes have a stimulating effect, caution against contact.
2. Ignition and explosion: A77 is 1726 flammable and may burn or explode when in contact with open flame, high temperature or oxidant.
3. Storage and handling: A77 1726 should be stored in a cool, dry, well-ventilated place, away from fire and oxidant. When handling A77 1726, be equipped with suitable personal protective equipment to avoid direct contact and inhalation.
In General, A77 1726 is an important fluorinated reagent, which has a wide range of applications in organic synthesis and surface treatment, but its toxicity and safety should be paid attention to when using it.
1. Physical properties: A77 1726 is a colorless liquid with a special pungent smell. It is less dense, with a melting point of -42 ° C and a boiling point of 79 ° C.
2. Chemical properties: A77 1726 is a highly reactive compound that can react with water and moisture in the air to generate strong hydrofluoric acid, so it should be handled in a dry environment. It can be used as a strong fluorination reagent for fluorination reactions in organic synthesis.
The main uses of A77 1726 include:
1. Organic Synthesis: as a fluorination reagent, A77 1726 can fluorinate the hydrogen atoms in organic matter to generate fluorinated compounds, which are widely used in the fields of medicine, pesticide and material science.
2. Surface treatment: A77 1726 can be used to fluorinate the surface of metal, plastic, glass and other materials to improve the wear resistance, temperature resistance and corrosion resistance of the surface.
A77 1726 can be prepared by the following steps:
1. Reacting fluoroacetyl fluoride (CF3COF) with hydrofluoric acid to produce fluoroacetyl fluoramide (CF3CONH2).
2. The A77 1726 is obtained by dehydration reaction of fluoroacetylfluoramine.
A77 1726 safety information is as follows:
1. Toxicity: A77 1726 has a certain toxicity, the skin and eyes have a stimulating effect, caution against contact.
2. Ignition and explosion: A77 is 1726 flammable and may burn or explode when in contact with open flame, high temperature or oxidant.
3. Storage and handling: A77 1726 should be stored in a cool, dry, well-ventilated place, away from fire and oxidant. When handling A77 1726, be equipped with suitable personal protective equipment to avoid direct contact and inhalation.
In General, A77 1726 is an important fluorinated reagent, which has a wide range of applications in organic synthesis and surface treatment, but its toxicity and safety should be paid attention to when using it.
Last Update：2024-04-09 20:49:11
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Multiple SpecificationsSpot supply
Product Name: Leflunomide Impurity 2（Leflunomide EP Impurity B） Visit Supplier Webpage Request for quotationCAS: 163451-81-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Teriflunomide Visit Supplier Webpage Request for quotationCAS: 163451-81-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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