108929-04-0

Name	Epinastine hydrochloride
Synonyms	Elestat Alesion WAL-801CL EPINASTIN HCL Epinastin Hcl EPINASTINE HCL Epinastine hcl Epinastine hydrochloride Epinastine Hydrochloride f)imidazo(1,5-a)azepin-3-amine,9,13b-dihydro-ih-dibenz(hydrochloride 9,13b-Dihydro-1H-Dibenz[c,f]imidazo[1,5-α]azepin-3-amine Hydrochloride 3-Amino-9,13b-Dihydro-1h-Dibenz[C,F]Imidazo[1,5-A]Azepine Hydrochloride 3-AMINO-9,13B-DIHYDRO-1H-DIBENZ[C,F]IMIDAZO[1,5-A]AZEPINE HYDROCHLORIDE
CAS	108929-04-0 80012-44-8
EINECS	629-843-8
InChI	InChI=1/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H
InChIKey	VKXSGUIOOQPGAF-UHFFFAOYSA-N

Molecular Formula	C16H16ClN3
Molar Mass	285.77
Melting Point	273-275°C
Boling Point	428°C at 760 mmHg
Flash Point	212.7°C
Solubility	H2O: soluble38mg/mL
Vapor Presure	1.56E-07mmHg at 25°C
Appearance	solid
Color	white
Storage Condition	2-8°C
MDL	MFCD00933434
In vitro study	In the guinea pig ileum, receptor binding studies showed that Epinastine has a high affinity for H1-receptors. At low concentrations, Epinastine was able to displace specific [Epinastine inhibited the release of histamine from rat peritoneal mast cells elicited by the antigen-antibody reaction and Compound 48/80 in Locust neural tissue. Epinastine was similarly effective in inhibiting Compound 48/80-induced histamine release from isolated rat peritoneal mast cells, or rat septal membranes. Epinastin not only can effectively inhibit Ca Epinastine show time-and dose-dependent inhibitory effect on IL-8, IL-8 is one of the Eosinophil chemotactic factors released by eosinophils isolated from allergic diseases.
In vivo study	Epinastine inhibits histamine-induced skin or lung responses in rats, dogs, and guinea pigs.

Hazard Symbols	T - Toxic
Risk Codes	25 - Toxic if swallowed
Safety Description	45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	HO4360000
HS Code	2933992600
Toxicity	LD50 in male, female rats (mg/kg): 314, 192 orally; 17, 22 i.v. (Nishikawa)

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CAS: 108929-04-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Spot supply

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108929-04-0

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