11-马来酰亚胺基十一烷酸琥珀酰亚胺酯

11-马来酰亚胺基十一烷酸琥珀酰亚胺酯 - Names and Identifiers

Name	N-Succinimidyl 11-(maleimido)undecanoate
Synonyms	NHS-(CH2)10-Mal (KMUS) Maleimide-(CH2)10-COONHS N-SUCCINIMIDYL 11-MALEIMIDOUNDECANOATE N-Succinimidyl 11-(maleimido)undecanoate N-(11-MALEIMIDOUNDECANOYLOXY)SUCCINIMIDE 11-Maleimidoundecanoic acid N-succinimidyl ester 11-(MaleiMido)undecanoic acid N-hydroxysucciniMide ester 1H-Pyrrole-2,5-dione, 1-[11-[(2,5-dioxo-1-pyrrolidinyl)oxy]-11-oxoundecyl]- N-(11-Maleimidoundecanoyloxy)succinimide, N-Succinimidyl 11-maleimidoundecanoate
CAS	87981-04-2

11-马来酰亚胺基十一烷酸琥珀酰亚胺酯 - Physico-chemical Properties

Molecular Formula	C19H26N2O6
Molar Mass	378.42
Density	1.25±0.1 g/cm3(Predicted)
Melting Point	90.0 to 94.0 °C
Boling Point	520.4±42.0 °C(Predicted)
pKa	-2.20±0.20(Predicted)
Storage Condition	2-8°C

11-马来酰亚胺基十一烷酸琥珀酰亚胺酯 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
FLUKA BRAND F CODES	10-21

11-马来酰亚胺基十一烷酸琥珀酰亚胺酯 - Introduction

N-succinimidyl ester of 11-maleimidoundecanoic acid (KMUS) is an important reagent commonly used in biochemical research.

Nature:
-Appearance: White solid
-Molecular formula: C21H33N3O5
-Molecular Weight: 407.50
-Melting point: 60-70°C
-Solubility: KMUS is soluble in organic solvents such as dimethyl sulfoxide and chloroform, but has low solubility in water

Use:
-Construction of biomolecular probes: KMUS can react with sulfhydryl groups on proteins, antigens or other biomolecules to achieve selective labeling or covalent linkage to them, for example, to prepare protein probes with fluorescent or emissive labels.
-Synthesis of fluorescent dyes: KMUS can be used as a precursor of fluorescent dyes to prepare fluorescent labeling agents with specific optical properties by combining with different fluorophores.

Preparation Method:
The synthesis of KMUS is mainly carried out by the condensation reaction of 11-maleimidoundecanoic acid (MUS) and succinimide (NHS). Specific reaction conditions and synthetic routes can be experimented with through literature or reference guides.

Safety Information:
- KMUS has a certain degree of irritation, please wear appropriate protective equipment, such as gloves and glasses, during operation.
-Avoid inhalation or direct skin contact. If you accidentally touch, please rinse immediately with plenty of water.
-reasonable storage, avoid high temperature and humid environment.

Last Update：2024-04-10 22:29:15

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