110-27-0
Isopropyl myristate
CAS: 110-27-0
Molecular Formula: C17H34O2
110-27-0 - Names and Identifiers
| Name | Isopropyl myristate |
| Synonyms | IPM IPM-R IPM-EX IPM 100 Estergel Radia 7730 (IPM) Isopropyl myristate propan-2-yl tetradecanoate ISO-PROPYL N-TETRADECANOATE MYRISTIC ACID ISOPROPYL ESTER MINIMU Tetradecanoic acid 1-methylethyl ester |
| CAS | 110-27-0 |
| EINECS | 203-751-4 |
| InChI | InChI=1/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3 |
| InChIKey | AXISYYRBXTVTFY-UHFFFAOYSA-N |
110-27-0 - Physico-chemical Properties
| Molecular Formula | C17H34O2 |
| Molar Mass | 270.45 |
| Density | 0.85 g/mL at 25 °C (lit.) |
| Melting Point | ~3 °C (lit.) |
| Boling Point | 193 °C/20 mmHg (lit.) |
| Flash Point | >230°F |
| JECFA Number | 311 |
| Water Solubility | Miscible with alcohol. Immiscible with water and glycerol. |
| Appearance | Transparent liquid |
| Specific Gravity | 0.855 (20/4℃) |
| Color | Clear |
| Merck | 14,5215 |
| BRN | 1781127 |
| Storage Condition | 2-8°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Refractive Index | n20/D 1.434(lit.) |
| MDL | MFCD00008982 |
| Physical and Chemical Properties | This product is colorless and tasteless liquid, miscible with vegetable oil. Not easy to hydrolysis and rancidity. Refractive index nD201.435 ~ 1.438, relative density (20 degrees C) 0.85~0.86. |
| Use | Widely used as a cream, cream, conditioner and other high-grade cosmetics additives |
110-27-0 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | - |
| RTECS | XB8600000 |
| TSCA | Yes |
| HS Code | 29159080 |
| Toxicity | LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
110-27-0 - Reference
| Reference Show more | 1. Yang Lixia, Zhao Jing, Wang Shan, et al. Effect of Dangshen Yuanzhi Powder Microemulsion on Learning and Memory Impairment in Alzheimer's Disease Model Mice [J]. Chinese Herbal Medicine 2020 v.51;No.664(05):174-180. 2. Ma Aiming, Jiang Shuguang, Huang Ling, Zhou Jianping. Preparation of Subcutaneous Insulin Injection Carrier Based on Brij97 Liquid Crystal [J]. Chinese Medical Science, 2014,4(04):64-67. 3. Ning Yuanlan, Shen Wen, Ao Fen. Preparation of Stable Nanoemulsion Based on Solubilized Quercetin [J]. Journal of Shaanxi University of Science and Technology, 2020, v.38;No.190(03):40-46. 4. Zhu Jinfang, Wu Jing, Ma Qiaoxia, etc.. Study on prescription selection and formulation technology of compound horse oil acne cream [J]. Research and practice of modern traditional Chinese medicine, 2020(3). 5. Song Jing, Zheng Yuan, Huo Changhong, et al. Study on quantitative structure retention relationship of phospholipid microemulsion electrokinetic chromatography [J]. Analytical Chemistry, 2017, 45(005):654-661. 6. Li Tong, Zhao Na, Shi Yu, etc. Optimization of Vitamin C Nanoemulsion Prescription and Its Percutaneous Permeability [J]. Journal of Shenyang Pharmaceutical University, 2018(7). 7. Liu Kaiping, Cheng Shengyong, Yu Linna, et al. Preparation and Quality Evaluation of Spider-scented Valerian Triester Self-microemulsion [J]. Chinese Journal of Experimental Prescription, 2018(11):16-21. 8. Qu Zihui, Zhang Bei, chen Yangyang, et al. Optimization of Preparation Process and Characterization of Tripterygium wilfordii Nanostructured Lipid Carrier [J]. China Pharmacy, 2019, 030(011):1470-1476. 9. Wan Jing, Chen Xiaolan, Yang Xiaomei, Yang Jinghong, Chen Yao, Yang Fangfang, Miao Yanyan. Investigation on penetration enhancer of furong mammography gel ointment [J]. Guizhou Science, 2020,38(05):7-10 67. 10. Xu Kunyong, Guo Jianzhong, Yan Juan, Yun Guoping. Study on Preparation Technology of Naringin Microemulsion [J]. China Pharmaceutical, 2020,29(23):36-40. 11. Ding Haibo, Lai Zhangting, Chen Xulong, Yuan Qili, Ouyang Liuqi, Liu Huan, Liao Zhenggen. Optimization of Andrographolide Self-nanoemulsion Prescription and Effect of Precipitation Inhibitor on Its Disperse Phase Behavior [J]. Chinese herbal medicine, 2020,51(16):4160-4168. 12. [IF = 2.952] Yulin Liang et al."Preparation and quality evaluation of a volatile oil microemulsion from Flos magnoliae and Centipeda minima." Mol Med Rep.2020 Dec;22(6):4531-4540 13. [IF = 4.932] Huawei Zhao et al.Azithromycin pretreatment exacerbates atopic dermatitis in trimellitic anhydride-induced model accompanied by correlated changes in the gut microbiota and series cytokines.Int Immunopharmacol. 2021 Nov;:108388 14. [IF = 6.321] Yujie Zheng et al."Microemulsion Delivery System Improves Cellular Uptake of Genipin and Its Protective Effect against Aβ1-42-Induced PC12 Cell Cytotoxicity." Pharmaceutics. 2022 Mar;14(3):617 |
110-27-0 - Reference Information
| FEMA | 3556 | ISOPROPYL MYRISTATE |
| LogP | 7.71 |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | isopropyl myristate is colorless to light yellow thin oily liquid, odorless and tasteless. Soluble in ethanol, ether, chloroform. Can be miscible with water. It has good lubricity and permeability, and can improve the affinity for the skin. It is a lower alcohol ester of higher fatty acids. |
| application | isopropyl myristate has low greasy feeling, softens the skin, and has good permeability. it is a solvent and retention agent for pigments, spices and various additives. Low melting point, stable and not easy to hydrolyze, color and smell can meet the requirements of cosmetics, is commonly used in cosmetics of excellent ester raw materials. |
| content analysis | accurately weigh about 1.5g of sample, and then determine according to ester determination method (OT-18). The equivalent factor (e) in the calculation is 135.2. Or by gas chromatography (GT-10-4) with non-polar column method. |
| toxicity | ADI is not specified (FAO/WHO,2001). |
| use | used as a dispersant for lipstick, hair cream, lipstick, cleaning cream, incense powder and medical ointment, and can also be used as a perfume fixative. It is suitable for use as a dispersant in cosmetics and pharmaceutical industries, and as a fixative for perfume. Carrier solvent. GB 2760-96 specifies food spices that are allowed to be used. is one of the important additives of high-grade cosmetics, which has excellent penetration, moisturizing and softening effects on the skin. It is used as an emulsifier and wetting agent for cosmetics. Used in organic synthesis. Solvent. Prepare spices oily raw materials for cosmetics and solvents for pesticides. Widely used as additives for advanced cosmetics such as creams, creams, and conditioners |
| production method | obtained by esterification of myristic acid and isopropanol after resteaming coconut oil. 200 kg of 14 acid and 450 kg of isopropanol are sequentially added into the reaction kettle, 360kg(98%) sulfuric acid is added after mixing, heated and refluxed for 10 h, isopropanol is recovered, acid is washed with ice water, neutralized with 10% Na2CO3 aqueous solution, isopropanol and water are evaporated under normal pressure, and the product is evaporated at 185 ℃/2.0 kPa ~ 195 ℃/2.7 kPa under reduced pressure. 90 kg of isopropanol is added into the reaction kettle, and then 5% of the total amount of sulfuric acid is added as catalyst. Under stirring, 228 kg of decadecanoic acid is slowly added, heated and refluxed, and the water is continuously divided into water. After the reaction is reached without water, the acid value is measured by cooling and sampling, and the acid value reaches 1.5 mg KOH/g as the end point. Add alkali to neutralize, remove water under reduced pressure, and dealcohol to an acid value of 0.05~1.0 mg KOH/g under reduced pressure. The discharge is the finished product. |
| spontaneous combustion temperature | >300°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:32:03
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