1115270-63-7
IAXO-102
CAS: 1115270-63-7
Molecular Formula: C35H71NO5
1115270-63-7 - Names and Identifiers
| Name | IAXO-102 |
| Synonyms | IAXO-102 Methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-α-D-glucopyranoside α-D-Glucopyranoside, methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl- |
| CAS | 1115270-63-7 |
1115270-63-7 - Physico-chemical Properties
| Molecular Formula | C35H71NO5 |
| Molar Mass | 585.96 |
| Density | 0.96±0.1 g/cm3(Predicted) |
| Boling Point | 650.2±55.0 °C(Predicted) |
| pKa | 13.00±0.70(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Use | IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. It inhibits MAPK and p65 N |
| In vitro study | IAXO-102 (1-10 µM, for 2 hours) inhibits MAPK and p65 NF-κB phosphorylation in human umbilical vein endothelial (HUVEC) cells. IAXO-102 (10 µM, for 17 hours) suppresses LPS induced proinflammatory proteins MCP-1 and IL-8 production in HUVEC. Western Blot Analysis Cell Line: Human umbilical vein endothelial (HUVEC) cells Concentration: 1-10 µM Incubation Time: Pretreatment for 1 hour and then exposed to LPS (100 ng/mL) for additional 1 hour Result: Significantly inhibited LPS-stimulated MAPK/p65nF-ΚB phosphorylation. |
| In vivo study | IAXO-102 (3 mg/kg/day, s.c. for 28 days) significantly retards Angiotensin II induced increase in aortic diameter in mice. Animal Model: Six-monthold ApoE −/− /C57Bl6 Dosage: 3 mg/kg/day Administration: S.C. for 28 days Result: Significantly retarded Angiotensin II-induced increase in aortic diameter. |
1115270-63-7 - Introduction
IAXO-102 is a chemical substance that has the following properties:
Nature:
-Chemical formula: determined according to the naming rules.
-Appearance: It may be solid, liquid or gas at room temperature.
-melting point and boiling point: According to the specific chemical substances to determine.
-density: according to the specific chemical substances to determine.
-solubility: according to the specific chemical substances to determine.
Use:
- IAXO-102 can be used as a specific chemical reagent. Depending on the specific use, it can be used for reactions, catalysts, reagents or other purposes in chemical experiments in the laboratory.
Preparation Method:
-There may be many methods for preparing IAXO-102, depending on the characteristics of the chemical substance and the needs of synthesis. For example, it can be synthesized through steps such as chemical reaction, separation and purification.
Safety Information:
-The safety of IAXO-102 is related to specific chemical substances. Before using or handling IAXO-102, you must have detailed safety information about their toxicity, flammability, explosiveness, and compatibility with other substances. In addition, it is also essential to follow proper laboratory practices and personal protective measures to ensure the safe use of chemical substances.
Nature:
-Chemical formula: determined according to the naming rules.
-Appearance: It may be solid, liquid or gas at room temperature.
-melting point and boiling point: According to the specific chemical substances to determine.
-density: according to the specific chemical substances to determine.
-solubility: according to the specific chemical substances to determine.
Use:
- IAXO-102 can be used as a specific chemical reagent. Depending on the specific use, it can be used for reactions, catalysts, reagents or other purposes in chemical experiments in the laboratory.
Preparation Method:
-There may be many methods for preparing IAXO-102, depending on the characteristics of the chemical substance and the needs of synthesis. For example, it can be synthesized through steps such as chemical reaction, separation and purification.
Safety Information:
-The safety of IAXO-102 is related to specific chemical substances. Before using or handling IAXO-102, you must have detailed safety information about their toxicity, flammability, explosiveness, and compatibility with other substances. In addition, it is also essential to follow proper laboratory practices and personal protective measures to ensure the safe use of chemical substances.
Last Update：2024-04-10 22:29:15
