112208

112208 - Names and Identifiers

Name	6,7-DIHYDRO-5H-1-PYRIDIN-5-ONE
Synonyms	112208 6,7-DIHYDRO-5H-1-PYRIDIN-5-ONE 6H,7H-cyclopenta[b]pyridin-5-one 6,7-DIHYDRO-5H-[1]PYRINDIN-5-ONE 6,7-dihydrocyclopenta[b]pyridin-5-one 6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDIN-5-ONE 5H-Cyclopenta[b]pyridin-5-one, 6,7-dihydro- 5H-cyclopenta[b]pyridine-5-one,6,7-dihydro-
CAS	28566-14-5

112208 - Physico-chemical Properties

Molecular Formula	C8H7NO
Molar Mass	133.15
Density	1.230±0.06 g/cm3(Predicted)
Melting Point	64-66 °C
Boling Point	125 °C(Press: 9 Torr)
pKa	3.47±0.20(Predicted)
Storage Condition	Inert atmosphere,Room Temperature

112208 - Reference Information

introduction

6,7-dihydro-5H-cyclopentano [B] pyridine -5-one, I .e. 6,7-dihydro-5H-cyclopentadiene and [B] pyridine -5-one, which can be composed of 6, 7-Dihydro-5H-cyclopentadienhe [B] pyridine is obtained by oxidation, and the oxidant can be hydrogen peroxide.

preparation

0.883mg Mn(OTf)2(0.5mol%),60mg 2,3-cyclopentenopyridine, 0.35g of 65% TBHP water
solution and 2.5ml of water were sequentially added to a 25mL round bottom flask, under the condition of room temperature in air for 24 hours, the reaction liquid is extracted with 3 ×
5mL ethyl acetate, the ethyl acetate layer is collected, dried with anhydrous sodium sulfate, filtered, evaporated ethyl acetate, petroleum ether and ethyl acetate with a volume ratio of
5:1 are used as eluents, and the product 6, 7-dihydro-5H-cyclopentano [B] pyridine -5-one 60.5mg is obtained by rapid silica gel column separation, light yellow solid with 91% yield. Melting point 62-63 ℃.

Last Update：2024-04-09 20:52:54