112883-43-9
(S)-N-FMOC-2-Naphthylalanine
CAS: 112883-43-9
Molecular Formula: C28H23NO4
112883-43-9 - Names and Identifiers
| Name | (S)-N-FMOC-2-Naphthylalanine |
| Synonyms | Fmoc-2-Nal-OH (S)-N-FMOC-2-Naphthylalanine Fmoc-L-3-(2-Naphthyl)-alanine Fmoc-3-(2-Naphthyl)-L-alanine (S)-N-Fmoc-3-(2-naphthyl)alanine N-ALPHA-FMOC-BETA-(2-NAPHTHYL)-L-ALANINE 3-Naphth-2-yl-L-alanine, N-FMOC protected FMOC-3 (2 NAPHTHYL)-L ALANINE FMOC-2-NAL-OH N-(9-FLUORENYLMETHOXYCARBONYL)-2-NAPHTHYL-L-ALANINE N-alpha-9-Fluorenylmethoxycarbonyl-3-(2-naphthyl)-D N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-3-(2-NAPHTHYL)-L-ALANINE |
| CAS | 112883-43-9 |
| InChI | InChI=1/C28H23NO4/c30-27(31)26(16-18-13-14-19-7-1-2-8-20(19)15-18)29-28(32)33-17-25-23-11-5-3-9-21(23)22-10-4-6-12-24(22)25/h1-15,25-26H,16-17H2,(H,29,32)(H,30,31)/p-1/t26-/m0/s1 |
| InChIKey | JYUTZJVERLGMQZ-SANMLTNESA-N |
112883-43-9 - Physico-chemical Properties
| Molecular Formula | C28H23NO4 |
| Molar Mass | 437.49 |
| Density | 1.2227 (rough estimate) |
| Melting Point | 155 °C |
| Boling Point | 549.64°C (rough estimate) |
| Flash Point | 371.6°C |
| Water Solubility | Slightly soluble in water. |
| Solubility | DMF (Sparingly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 4.95E-20mmHg at 25°C |
| Appearance | Light brown powder |
| Color | White to Off-White |
| pKa | 3.77±0.30(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6290 (estimate) |
| MDL | MFCD00144886 |
112883-43-9 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
112883-43-9 - Introduction
Fmoc-L-beta-naphthylphenylalanine is an organic compound with the following properties:
1. Appearance: white solid
2. Solubility: Soluble in organic solvents such as methanol, dichloromethane and dimethyl sulfoxide
3. molecular formula: C27H25NO4
4. Molecular weight: 423.49g/mol
5. Melting point: 172-176°C
6. storage conditions: should be stored in a dry, cool place, avoid direct sunlight and humid environment
7. use: Fmoc-L-β-naphthyl phenylalanine is an important amino acid derivatives, commonly used in solid phase synthesis of peptide and protein synthesis, mainly used for the reaction of protecting amino groups.
Preparation Method:
The preparation method of Fmoc-L-β-naphthylphenylalanine is generally carried out by the following steps:
1. L-β-naphthylphenylalanine was dissolved in a mixed solution of dimethyl sulfoxide/DIPEA (diisopropylethylamine) to be sufficiently dissolved.
2. Fmoc-OSu(N-carbonyl determinant) is gradually added to the solution and reacted for a period of time.
3. crystal removed, washed and dried to obtain pure product.
Safety Information:
The following safety precautions should be taken when handling Fmoc-L-β-naphthylphenylalanine:
1. Avoid inhaling dust or solution gas.
2. Avoid direct contact with the skin. If in contact, rinse with plenty of water immediately.
3. during operation should wear appropriate protective gloves, glasses and protective mask.
4. should be stored away from fire and high temperature.
1. Appearance: white solid
2. Solubility: Soluble in organic solvents such as methanol, dichloromethane and dimethyl sulfoxide
3. molecular formula: C27H25NO4
4. Molecular weight: 423.49g/mol
5. Melting point: 172-176°C
6. storage conditions: should be stored in a dry, cool place, avoid direct sunlight and humid environment
7. use: Fmoc-L-β-naphthyl phenylalanine is an important amino acid derivatives, commonly used in solid phase synthesis of peptide and protein synthesis, mainly used for the reaction of protecting amino groups.
Preparation Method:
The preparation method of Fmoc-L-β-naphthylphenylalanine is generally carried out by the following steps:
1. L-β-naphthylphenylalanine was dissolved in a mixed solution of dimethyl sulfoxide/DIPEA (diisopropylethylamine) to be sufficiently dissolved.
2. Fmoc-OSu(N-carbonyl determinant) is gradually added to the solution and reacted for a period of time.
3. crystal removed, washed and dried to obtain pure product.
Safety Information:
The following safety precautions should be taken when handling Fmoc-L-β-naphthylphenylalanine:
1. Avoid inhaling dust or solution gas.
2. Avoid direct contact with the skin. If in contact, rinse with plenty of water immediately.
3. during operation should wear appropriate protective gloves, glasses and protective mask.
4. should be stored away from fire and high temperature.
Last Update：2024-04-10 22:29:15
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CAS: 112883-43-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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