112960-16-4

Name	PD128907 HCl
Synonyms	PD 125,530 PD128907 HCl rel-(4aR,10bR)-4-Propyl-2,3,4,4a,5,10b-hexahydrochromeno[4,3-b][1,4]oxazin-9-ol hydrochloride (4aR,10bR)-rel-4-Propyl-2,3,4,4a,5,10b-hexahydrochromeno[4,3-b][1,4]oxazin-9-ol hydrochloride PD 125,530, trans-(±)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride
CAS	112960-16-4

Molecular Formula	C14H19NO3.ClH
Molar Mass	285.769
Melting Point	>220 °C (decomp)
Solubility	H2O: >5mg/mL
Appearance	solid
Color	white
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
MDL	MFCD00210210
In vitro study	PD 128907 HCl is a potent and selective dopamine D3 receptor agonist with an EC50 of 0.64 nM, which is 53 times more selective than that at the dopamine D2 receptor. The use of [PD 128907 in CHOKl-cells is used to study the role of these receptors in the brain, such as inhibiting self-receptors, which in turn restrict dopamine release.
In vivo study	In normal and γ-butyrolactone (GBL)-treated rats, PD 128907 was effective in reducing DA synthesis. PD 128907 (3 mg/kg) attenuated the toxicity of cocaine overdose and completely inhibited the convulsive and lethal effects induced by cocaine. This protective effect is exerted by a D3 coupled mechanism, which also has a protective effect on seizures.

WGK Germany

(±)-PD 128,907 hydrochloride

Last Update：2022-10-16 17:41:56

biological activity	PD128907 HCl is a potent, selective dopamine D3 receptor agonist with an EC50 of 0.64 nM, it is 53-fold more selective than acting on the dopamine D2 receptor. PD128907 HCl is a potent, selective dopamine D3 receptor agonist with an EC50 of 0.64 nM, 53-fold higher than the selectivity for dopamine D2 receptors.
Target	Value
D3 receptor	0.64 nM(EC50)

Last Update：2024-04-09 21:54:55

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CAS: 112960-16-4
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112960-16-4

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