Name | 7-Ethyl-10-hydroxycamptothecin |
Synonyms | SN-38 Intermediate of Irinotecan 1 7-Ethyl-10-hydroxycamptothecin 7-ethyl-10-hydroxy camptothecin 7-Ethyl-10-Hydroxy-Camptothecin 7-Ethyl-10-hydroxycamptothecine 7-ethyl-10-hydroxy-camptothecine (rac)-7-Ethyl-10-Hydroxy camptothecin rac-4,11-Diethyl-9-hydroxycamptothecin (110714-48-2) 7-ethyl-10-hydroxycamptothecin |
CAS | 86639-52-3 130194-92-2 119577-28-5 130144-34-2 110714-48-2 113015-38-6 |
InChI | InChI=1/C20H16N2O5/c1-2-20(26)13-7-15-17-10(6-11-14(21-17)4-3-5-16(11)23)8-22(15)18(24)12(13)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1 |
Molecular Formula | C22H20N2O5 |
Molar Mass | 392.4 |
Density | 1.51 |
Melting Point | 217°C |
Boling Point | 810.3±65.0 °C(Predicted) |
Specific Rotation(α) | 21.5 ° (C=0.2, THF) |
Solubility | Slightly soluble in methanol, ethanol, chloroform, soluble in DMSO, insoluble in water. |
Appearance | White-like crystal |
pKa | 9.13±0.40(Predicted) |
Storage Condition | 2-8℃ |
Refractive Index | 1.776 |
MDL | MFCD06762720 |
Physical and Chemical Properties | Properties: yellowish white crystalline powder, soluble in dimethyl sulfoxide, slightly soluble in methanol |
Use | Purposes: hydroxycamptothecin is the preparation of anti-tumor drug irinotecan hydrochloride (CPT-11) key intermediates. |