113400-36-5
2-benzyl 1-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate
CAS: 113400-36-5
Molecular Formula: C17H21NO5
113400-36-5 - Names and Identifiers
| Name | 2-benzyl 1-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate |
| Synonyms | Boc-Pyr-Obzl Boc-PyroglutaMic acid. Benzyl ester BOC-L-PYROGLUTAMIC ACID BENZYL ESTER (S)-2-Benzyl 1-tert-butyl 5-oxopyrrolidine-1,2-dicarboxylate 2-benzyl 1-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate 2-O-benzyl 1-O-tert-butyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate (2R)-5-Oxo-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-(phenylmethyl) ester 1,2-Pyrrolidinedicarboxylic acid, 5-oxo-, 1-(1,1-diMethylethyl)2-(phenylMethyl) ester, (S)- |
| CAS | 113400-36-5 |
| InChI | InChI=1/C17H21NO5/c1-17(2,3)23-16(21)18-13(9-10-14(18)19)15(20)22-11-12-7-5-4-6-8-12/h4-8,13H,9-11H2,1-3H3/t13-/m0/s1 |
113400-36-5 - Physico-chemical Properties
| Molecular Formula | C17H21NO5 |
| Molar Mass | 319.35 |
| Density | 1.219 |
| Melting Point | 69-70 °C |
| Boling Point | 464.9±38.0 °C(Predicted) |
| Flash Point | 234.991°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder |
| Color | White |
| pKa | -4.32±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.542 |
| MDL | MFCD04115781 |
113400-36-5 - Introduction
Benzyl N-tert-butoxycarbonyl-L-pyroglutamic acid ester is a compound whose structure contains N-tert-butoxycarbonyl and benzyl ester functional groups.
Its nature:
1. appearance: generally colorless solid or crystalline solid.
2. Solubility: Soluble in organic solvents, such as dimethyl sulfoxide and dichloromethane.
3. melting point: the melting point is higher, about 60-70 degrees Celsius.
Use:
N-tert-butoxycarbonyl-L-pyroglutamic acid benzyl ester has certain application value in the field of medicine. It is commonly used as a synthetic intermediate of a compound for the preparation of biologically active substances such as acylating agents, phosphating agents and substrates in the synthesis of pharmaceuticals.
Preparation Method:
The preparation of N-tert-butoxycarbonyl-L-pyroglutamic acid benzyl ester can be carried out by the esterification reaction of benzyl alcohol and N,N-dimethylethanolamine in the presence of tert-butyl carbonate. The reaction is usually carried out at room temperature or with heating to the melting point of the reaction product.
Safety Information:
1. N-tert-butoxycarbonyl-L-pyroglutamic acid benzyl ester has low toxicity to human body under normal operating conditions.
2. in the operation should pay attention to prevent inhalation, contact with skin and food, and maintain good ventilation conditions.
3. use should wear appropriate protective gloves and goggles, avoid contact with skin and eyes.
4. In case of accidental exposure or ingestion, seek medical attention immediately and bring relevant product information or labels.
Its nature:
1. appearance: generally colorless solid or crystalline solid.
2. Solubility: Soluble in organic solvents, such as dimethyl sulfoxide and dichloromethane.
3. melting point: the melting point is higher, about 60-70 degrees Celsius.
Use:
N-tert-butoxycarbonyl-L-pyroglutamic acid benzyl ester has certain application value in the field of medicine. It is commonly used as a synthetic intermediate of a compound for the preparation of biologically active substances such as acylating agents, phosphating agents and substrates in the synthesis of pharmaceuticals.
Preparation Method:
The preparation of N-tert-butoxycarbonyl-L-pyroglutamic acid benzyl ester can be carried out by the esterification reaction of benzyl alcohol and N,N-dimethylethanolamine in the presence of tert-butyl carbonate. The reaction is usually carried out at room temperature or with heating to the melting point of the reaction product.
Safety Information:
1. N-tert-butoxycarbonyl-L-pyroglutamic acid benzyl ester has low toxicity to human body under normal operating conditions.
2. in the operation should pay attention to prevent inhalation, contact with skin and food, and maintain good ventilation conditions.
3. use should wear appropriate protective gloves and goggles, avoid contact with skin and eyes.
4. In case of accidental exposure or ingestion, seek medical attention immediately and bring relevant product information or labels.
Last Update：2024-04-09 02:00:41
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