1142199-56-1
(4E)-3-(Chloromethyl)-4-(1H-indol-3-ylmethylene)-isoxazol-5(4H)-one
CAS: 1142199-56-1
Molecular Formula: C13H9ClN2O2
1142199-56-1 - Names and Identifiers
1142199-56-1 - Physico-chemical Properties
| Molecular Formula | C13H9ClN2O2 |
| Molar Mass | 260.68 |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD12027815 |
1142199-56-1 - Risk and Safety
| Hazard Class | IRRITANT |
1142199-56-1 - Introduction
(4E)-3-(Chloromethyl)-4-(1H-indol-3-ylmethylene)-isoxazol-5(4H)-one is an organic compound. The following is its nature, use, preparation and safety information:
Nature:
(4E)-3-(Chloromethyl)-4-(1H-indol-3-ylmethylene)-isoxazol-5(4H)-one is a white solid. Its chemical formula is C14H9ClN2O2 and its relative molecular mass is 272.68g/mol. It is insoluble in water at normal temperature, but soluble in organic solvents such as ether and methylene chloride.
Use:
(4E)-3-(Chloromethyl)-4-(1H-indol-3-ylmethylene)-isoxazol-5(4H)-one has potential applications in the field of drug research. It may be used as an anti-cancer drug candidate because of its possible role in the growth and division of cancer cells. In addition, it may also have antibacterial and anti-inflammatory effects.
Preparation Method:
The synthesis of (4E)-3-(Chloromethyl)-4-(1H-indol-3-ylmethylene)-isoxazol-5(4H)-one is complicated. A common synthetic method involves the reaction of benzoic acid and 2-aminobenzaldehyde to give 1H-indole, followed by reaction with chloroacetic acid to give (Cl)-methyl-3-(indol-3-yl)-2-propenoic acid methyl ester. Finally, (Cl)-methyl-3-(indol-3-yl)-2-propenoic acid methyl ester was reacted with sodium hydroxide and ethylene oxide to obtain the target product.
Safety Information:
No detailed toxicological data are available for the safety of (4E)-3-(Chloromethyl)-4-(1H-indol-3-ylmethylene)-isoxazol-5(4H)-one. However, as a chemical substance, it may cause some harm to the human body. When using or handling it, follow relevant laboratory safety practices and personal protection measures, such as wearing appropriate protective gloves, eye protection and protective clothing. In addition, avoid mixing with other chemicals and avoid contact with fire sources during storage and handling. Store it in a dry, well-ventilated place. If necessary, the relevant laboratory experts should be consulted or refer to the safety data form.
Nature:
(4E)-3-(Chloromethyl)-4-(1H-indol-3-ylmethylene)-isoxazol-5(4H)-one is a white solid. Its chemical formula is C14H9ClN2O2 and its relative molecular mass is 272.68g/mol. It is insoluble in water at normal temperature, but soluble in organic solvents such as ether and methylene chloride.
Use:
(4E)-3-(Chloromethyl)-4-(1H-indol-3-ylmethylene)-isoxazol-5(4H)-one has potential applications in the field of drug research. It may be used as an anti-cancer drug candidate because of its possible role in the growth and division of cancer cells. In addition, it may also have antibacterial and anti-inflammatory effects.
Preparation Method:
The synthesis of (4E)-3-(Chloromethyl)-4-(1H-indol-3-ylmethylene)-isoxazol-5(4H)-one is complicated. A common synthetic method involves the reaction of benzoic acid and 2-aminobenzaldehyde to give 1H-indole, followed by reaction with chloroacetic acid to give (Cl)-methyl-3-(indol-3-yl)-2-propenoic acid methyl ester. Finally, (Cl)-methyl-3-(indol-3-yl)-2-propenoic acid methyl ester was reacted with sodium hydroxide and ethylene oxide to obtain the target product.
Safety Information:
No detailed toxicological data are available for the safety of (4E)-3-(Chloromethyl)-4-(1H-indol-3-ylmethylene)-isoxazol-5(4H)-one. However, as a chemical substance, it may cause some harm to the human body. When using or handling it, follow relevant laboratory safety practices and personal protection measures, such as wearing appropriate protective gloves, eye protection and protective clothing. In addition, avoid mixing with other chemicals and avoid contact with fire sources during storage and handling. Store it in a dry, well-ventilated place. If necessary, the relevant laboratory experts should be consulted or refer to the safety data form.
Last Update：2024-04-09 21:00:56
