1143532-39-1

Name	4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-
Synonyms	AZD5363 AZD5356 AZD-5363 AZD5363 AZD 5363 AZD 5363 AZD-5363 CAPIVASERTIB AZD 5363 dihydrochloride (S)-4-Amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidi 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide 4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide AZD5363
CAS	1143532-39-1

Molecular Formula	C21H25ClN6O2
Molar Mass	428.92
Density	1.381
Melting Point	161-164°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	Off-White to Pale Beige
pKa	13.93±0.50(Predicted)
Storage Condition	Refrigerator
In vitro study	AZD5363 is a potent inhibitor of Akt, inhibiting Akt1, Akt2 and Akt3 with IC50 of 3 nM, 8 nM and 8 nM, respectively. The activation of PIK3CA mutation, the loss or inactivation of the tumor suppressor gene PTEN, or the amplification of HER2 all have a significant relationship with AZD5363. Furthermore, a correlation between the RAS mutational status of the cell lines and the anti-azd5363 can also be seen. AZD5363 inhibited phosphorylation of AKT substrates in cells with a titer of about 0.3~0.8 μm. AZD5363 inhibited cell proliferation in 41 of 182 solid and hematologic tumor cell lines with a titer of <3 μm.
In vivo study	AZD5363 was orally administered to nude mice at a dose of 100,300 mg/kg to reduce the phosphorylation of PRAS40, GSK3β, and S6 in the transplanted tumor of BT474c in a dose-and time-dependent manner, it also reversibly increases blood glucose concentration and reduces 2 [

Last Update：2024-01-02 23:10:35

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Product Name: Capivasertib (AZD-5363) Request for quotation
CAS: 1143532-39-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Spot supply

Wechat: 18301782025

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1143532-39-1

1143532-39-1 Request for Quotation