Molecular Formula | C43H53NO14 |
Molar Mass | 807.88 |
Density | 1.38 |
Melting Point | 186-192°C (dec.) |
Boling Point | 900.5±65.0 °C(Predicted) |
Specific Rotation(α) | -36 º (c=0.74,EtOH) |
Water Solubility | Soluble in dimethyl sulfoxide and ethanol. Insoluble in water. |
Solubility | Soluble in ethanol, acetone, ether, benzene and other organic solvents. |
Appearance | White crystalline powder |
Color | White |
Merck | 14,3397 |
pKa | 11.20±0.46(Predicted) |
Storage Condition | Sealed in dry,Store in freezer, under -20°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
Refractive Index | 1.618 |
MDL | MFCD00800737 |
Physical and Chemical Properties | Melting point 232°C specific optical rotation -36 ° (c = 0.74,EtOH) |
Use | Antineoplastic botanicals for the treatment of metastatic breast cancer and non-small cell lung cancer |
Hazard Symbols | Xi - Irritant |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R61 - May cause harm to the unborn child |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | 1544 |
WGK Germany | 3 |
RTECS | DA4172750 |
HS Code | 29322090 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 intravenous in dog: 2500ug/kg |
Reference Show more | 1. Li Fei Wang Jianzhu Bi Yanping. Preparation of docetaxel liposomes by freeze-drying method of tert-butanol-water co-solvent system [J]. Chinese Journal of Pharmacy 2016 51(004):293-297. 2. Li Fei, Zhang Na, Hao Jifu, et al. Preparation and characterization of docetaxel nanoliposomes [J]. Journal of Taishan Medical College, 2015, 36(010):1096-1099. 3. [IF = 1.871] Lining Wang et al."Establishment of a first-line second-line treatment model for human pulmonary adenocarcinoma." Oncol Lett. 2016 Dec;12(6):4461-4466 4. [IF = 6.419] Lili Ren et al."RGD-targeted redox responsive nano micelle: co-loading docetaxel and indocyanine green to treat the tumor." Drug Deliv. 2021;28(1):2024-2032 5. [IF = 2.441] Ha Yinuer et al."Herb-Drug Interaction Potential of Licorice Extract and Paclitaxel: A Pharmacokinetic Study in Rats." Eur J Drug Metaph. 2020 Apr;45(2):257-264 |