Molecular Formula | C15H16N6O3 |
Molar Mass | 328.33 |
Density | 1.41±0.1 g/cm3(Predicted) |
Melting Point | >190° (dec.) |
Boling Point | 502.2±60.0 °C(Predicted) |
Solubility | DMSO : 83.33 mg/mL (253.80 mM; Need ultrasonic) |
Appearance | Solid |
Color | Light Beige to Beige |
pKa | 1.36±0.29(Predicted) |
Storage Condition | Refrigerator, Under inert atmosphere |
In vitro study | IOX4 (1-100 μM; 5 hours) determines the EC 50 s for HIF1α induction are 114 μM, 86 μM and 49.5 μM in MCF-7, Hep3B and U2OS, respectively. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.046 ml | 15.229 ml | 30.458 ml |
5 mM | 0.609 ml | 3.046 ml | 6.092 ml |
10 mM | 0.305 ml | 1.523 ml | 3.046 ml |
5 mM | 0.061 ml | 0.305 ml | 0.609 ml |
biological activity | IOX4 is a potent and selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor, the IC50 was 1.6 nM. IOX4 can induce HIF Alpha in a variety of mouse tissues and human cell lines. |
Target | Value |
HIF-1α () | |
HIF-2α () | |
PHD2 (Cell-free assay) | 1.6 nM |