115939-25-8
Salvianolic acid B
CAS: 115939-25-8
Molecular Formula: C36H30O16
115939-25-8 - Names and Identifiers
115939-25-8 - Physico-chemical Properties
| Molecular Formula | C36H30O16 |
| Molar Mass | 718.61 |
| Density | 1.637g/cm3 |
| Melting Point | >149oC (dec.) |
| Boling Point | 1020.3°C at 760 mmHg |
| Flash Point | 322.1°C |
| Solubility | Soluble in water, ethanol, methanol. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Yellow powder |
| Color | Pale Yellow to Yellow |
| Storage Condition | -20°C Freezer |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.739 |
| Physical and Chemical Properties | White-like crystalline powder, soluble in water, ethanol and methanol, derived from the rhizome of Salvia miltiorrhiza. |
115939-25-8 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29329990 |
115939-25-8 - Reference
| Reference Show more | 1. Niu Min, Liu Hongyan, Liu Qian, etc Correlation between the color of Salvia miltiorrhiza and the content of nine active components in four cultivation years [J] Chinese patent medicine 2017 (1): 131-135. < br > 2. Liu Lan, Li Ya, Guo Zhihua, Yi Lijuan, Zou Sulan, Guo Ziyan. Study on spray drying process of Liqi Huoxue compound extract by box Behnken response surface methodology combined with G1 entropy weight method [J] Chinese herbal medicine 2019 50 (11): 2560-2566. 3. Huang Xiang, He Yu, Yang Jiehong, etc Study on the quality control of effective components and active parts of Danhong injection by HPLC-DAD and UV-VIS [J] Chinese Journal of Traditional Chinese Medicine 2013 028 (004): 1066-1070. 4. Min Min, Zhao Zhiguo, Liu Wei, etc Simultaneous Determination of Water Soluble and Fat Soluble Components in Salvia Miltiorrhiza from Three Sources by HPLC-DAD [J] Shandong Science 2019 (6). 5. Yang Chunmei, Cao Weiyi, Lin Jiahao, etc Study on pharmacokinetic parameters of main components of SPG compound in rats [J] Journal of Liaoning University of Traditional Chinese Medicine 2018 020 (010): 32-35. 6. Yan Yan, Shi Lei, Shi Ning, Guo Hongju, Geng Shuai, Wen Binyu. UPLC-Q-TOF-MS simultaneous determination of the main components of salvia miltiorrhiza in Tianwang Buxin tablets [J] Journal of PLA Pharmacy 2018 34 (01): 55-57. 7. Shi Weihua, Zhao Xiaoping, Chen Xiaoling Screening of DPP-4 Inhibitors from Sanye Tangzhiqing and Study on the Mechanism of Regulating JNK/AKT Signal Pathway to Improve Insulin Resistance [J] Journal of Zhejiang University of Traditional Chinese Medicine 2019 43 (01): 7-13. 8. Feng Huainan, Wang Rui, Gu Wen, et al Effects of red and blue light quality with different intensities on root morphology and accumulation of active components of Salvia miltiorrhiza [J] Chinese herbal medicine 2019 (21). 9. 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Wei Guangfei, Liu Qian, Li Jia, et al Study on the distribution of active components in the root of Salvia miltiorrhiza [J] Shandong Science 2015 28 (05): 7-13. 14. Wei Guangfei, Li Cui, Liu Qian, etc Study on the correlation between the root diameter of Salvia miltiorrhiza and the content of its active components [J] Chinese patent medicine 2015 37 (008): 1780-1784. 15. Wei Guangfei, Li Jia, Liu Qian, etc Study on the correlation between root color and active ingredient content of Salvia miltiorrhiza [J] Shandong Agricultural Sciences 2015 (08): 59-62. 16. Shi Jie, Geng Xiaokang, SHI, et al Study on the therapeutic effect and mechanism of salvianolic acid B on chronic nephritis rats [J] PLA Medical Journal 2017 10 (v.33; No.218): 11-15. 17. Ai Jinchao, He Yu, Yang Rongbing, etc Study on pharmacokinetics of main active components in Danhong injection in rats with cerebral ischemia [J] Chinese herbal medicine 2015 46 (20): 79-84. 18. Zhou Huifen, He Yu, Ai Jinchao, etc Pharmacokinetic study on the compatibility of main effective components of Danhong injection in rats with cerebral ischemia reperfusion [J] Chinese herbal medicine 2016 (20). 19. Yang Chunmei, Cao Weiyi, Hou Junling, etc Study on pharmacokinetic parameters of salvianolic acid B, paeoniflorin and glycyrrhizic acid in rats [J] Northwest Journal of Pharmacy 2018 33 (03): 94-99. 20. Liu Pei, Fu Junqiu, Shao Tiemei, Jiao Zhan, Li Xuewu, Tao Anshengjun. The effects of salvianolic acid B and tanshinone Ⅱ A on the proliferation of rat thoracic aorta adventitia fibroblasts [J] Chinese Pharmacological Bulletin 2017 33 (07): 991-996. 21. Du Qiu, Du Shouying, Li Pengyue, etc Study on nasal circulation absorption of salvianolic acid B in rats in vivo [J] Chinese Journal of Traditional Chinese Medicine 2016 41 (002): 303-308. 22. Guo Eping, Yang Shuguo, Zhang Zhen, et al Effect of salvianolic acid B on MMP-1 and TIMP-1 of liver fibrosis in mice with schistosomiasis japonica [J] Shaanxi Medical Journal 2014 000 (003): 259-261. 23. Zhu Yuanmei, Yin Bujin, Zhang Xu, etc Effect of salvianolic acid B on phenotype transformation and extracellular matrix secretion of glomerular mesangial cells induced by high glucose [J] Chinese Journal of Pathophysiology 2019 35 (02): 248-252. 24. Chen Zengfeng, Luo Tao. Salvianolic acid B inhibits TLR2/NF- κ B Study on the effect of improving rheumatoid arthritis in rats [J] Hebei Medicine 2019 41 (05): 765-767. 25. Guo Eping, Yang Shuguo, Zhang Zhen, et al Experimental study on the effect of salvianolic acid B on liver fibrosis in mice with schistosomiasis japonica [J] Modern Preventive Medicine 2014 41 (19): 3562-3565. 26. Du Qiutan, Ning Luyang, et al Studies on in vivo nasal absorption and in vitro blood brain barrier cell absorption of salvianolic acid B liquid crystal nanoparticles [J] Chinese Journal of Traditional Chinese Medicine 2017 032 (007): 3140-3143. 27. Li Qingqing, Zhang Jifen Determination of 14 components in Guanxinning [J] Suyan Science and Technology 2019 046 (006): 33-35. 28. Bai Yidan, Qiao Zhou, Xue Jingwei, et al Simultaneous Determination of Multi components in Shensong Yangxin Capsule and Validation of Methodology [J] Journal of Pharmaceutical Analysis 2018 v.38 (08): 80-90. 29. Wang Yixuan, Li Haitao, Liu Shun, etc Study on the Quality Standard of Shenkuitongmai Granules [J] New Traditional Chinese Medicine and Clinical Pharmacology, Volume 31, Issue 8, 2020, Page 984-989, ISTIC PKU CSCD CA 2020. 30. Shi Gongde, Zhou Jing, Li Min, etc Study on the extraction process of salvianolic acid B in the prescription of invigorating qi and activating blood circulation based on R language [J] Chinese Medical Emergency, 2017 (10): 13-15+19. 31. Yi Lijuan, Li Ya, Zou Sulan, et al Optimization of water extraction process of Yiqi Huoxue Formula based on orthogonal experimental design and BP neural network [J] Chinese herbal medicine, 2019, v.50; No.653 (18): 50-57. 32. Li Zheng, Pan Wanfang, Zhu Liming, etc Study on quality control of Danhong injection pharmaceutical process based on material flow analysis [J] Journal of Tianjin University of Traditional Chinese Medicine, 2015, 34 (06): 349-352. 33. Yi Lijuan, Li Ya, Liu Lan, etc Study on HPLC fingerprint of Xintongtai granules [J] Chinese herbal medicine, 2019, v.50; No.657 (22): 95-100. 34. Li Cui, Wei Guangfei, Li Jia, etc Study on the Utilization Value of Salvia Miltiorrhiza with Abnormal Characters [J] Shandong Science, 2014, 27 (002): 39-43. 35. Wu Yan, Geng Kuikui, Deng Xiaomei, etc Determination of salvianolic acid B in salvianolic acid salt for injection by improved HPLC [J] China Pharmacy, 2016 (36). 36. Huang Juan, Qiu Xiaohui, Bai Junqi, et al Quality evaluation of rhizomatous medicinal material Salvia miltiorrhiza precision decoction pieces [J] Chinese Journal of Experimental Formulas, 2017, 023 (011): 18-22. 37. Wu Yan, Geng Kuikui, Shi Tianlu, etc Stability of finished infusion of salvianolic acid salt for injection [J] Anhui Medical Journal, 2018, 22 (6): 1203-1206. 38. Liu Yun, Ren Hongqi, Wang Zenghui, Yang Yang, Dai Deshu, Liu Xiang, Hu Xueqing, Li Xiangyang, Liu Ying, Tang Renxian The effect of total phenolic acid extract of Salvia officinalis on the expression of Toll like receptor 4 in podocytes injured by puromycin aminonucleoside [J]. Chinese Journal of Nephropathy of Integrated Traditional and Western Medicine, 2017,18 (08): 672-675. 39. Summer Day, Shuchang, Sun Miao, et al Improvement of quality standard of Yiqi Xingnao Drink [J] Chinese Journal of Hospital Pharmacy, 2017, 037 (023): 2364-2367. 40. Wang Chuang, Liu Tingyue Thermodynamic study on static adsorption of salvianolic acid B by ion exchange fiber [J] Journal of Beijing University of Chemical Technology (Natural Science Edition), 2012 (06): 17-22. 41. Zhao Zhiguo, Duan Wenjuan, Zhang Xiaomeng, etc Identification and Determination of Various Components in Qianliexin Capsules by HPLC-DAD-ESI-TOF/MS and Study on Multi index Quantitative Fingerprint [J] Journal of Pharmaceutical Analysis, 2017, 037 (010): 1810-1816. 42. Peng Jiuman, Chai Yao, Pan Min, etc Transformation relationship of phenolic acids in Salvia miltiorrhiza under different technological conditions [J] Chinese Journal of Experimental Formulas, 2016, 022 (005): 67-70. 43. Wang Yun, Chen Junfeng, Zhang Lei, et al Study on the evaluation of Salvia miltiorrhiza quality based on the association analysis of "active components traits" [J] World Science and Technology: Modernization of Traditional Chinese Medicine, 2019 (5): 835-843. 44. Huang Zhaogang, Cheng Gang, Tang Hao, etc Study on the Fingerprint of Xuebijing Injection [J] Chinese Journal of Hospital Pharmacy, 2018, 038 (022): 2323-2327. 45. Zheng Wenhua, Xi Yaya, Qu Congcongcong, etc Quality evaluation of standard decoction of red sage root Chinese Journal of Experimental Formulas. 46. Cui Weiliang Comparison of HPLC Fingerprint Peak Attribution of Salvia Miltiorrhiza before and after Liquor broiling [J] Liaoning Journal of Traditional Chinese Medicine, v.46; No.507 (08): 1707-1709. 47. Li Jiancheng, Feng Bin Observation of salvianolic acid B on lung tissue repair and brain nerve protection in young mice with Staphylococcus aureus pneumonia [J]. Journal of Zhengzhou University (Medical Edition), 2021,56 (01): 102-108. 48. He Shan, Fu Xianjun, Zhang Ling, Peng Xiao, Wang Zhenguo. Response surface methodology for optimizing the extraction process of effective components of Salvia miltiorrhiza and their antioxidant activity in vitro [J]. Chinese Journal of Traditional Chinese Medicine, 2021,39 (01): 28-32+266-267. 49. Ye Shuqing, Wu Qingping, Zheng Yujun, Xu Qilong, Zou Yucen, Li Cunyu, Dong Zhengqi. Nanofiltration separation law of salvianolic acid B and matrine in complex solution environment based on critical separation effect [J]. Chinese Patent Medicine, 2021,43 (02): 314-320. 50. Wang Li, Li Muyao, Sun Sitong, Zhang Wenjun, Lv Jiangwei, Cui Wenyu. Study on the preparation and release mechanism of salvianolic acid B controlled release capsules based on osmotic pressure principle [J]. Zhongnan Pharmacy, 2021,19 (02): 198-202. 51. Gao Ruilin, Yang Pengshuo, Xu Gang, Wu Xiaowen, Yang Chang, Shi Xinyuan. Near infrared quantitative modeling of salvianolic acid B in Naoxintong capsule based on the idea of system modeling [J]. Spectroscopy and spectral analysis, 2020, 40 (11): 3573-3578. 52. Le Shijun, Wang Wenxiao, Gao Huan, Ren Jiguo, Fu Ruijia, Li Jiajia, Chen Yanyan, Tang Yuping. Simultaneous determination of multiple effective ingredients in Dan Qi tablets from different manufacturers by HPLC [J]. Journal of Pharmaceutical Analysis, 2020,40(12):2236-2243. 53. Cao, Weiyi, et al. "Simultaneous Quantification of Aspirin, Its Metabolite Salicylic Acid, and Salvianolic Acid B in Human Plasma Using UPLC-MS/MS." International Journal of Analytical Chemistry 2021 (2021). 54. Li J, Liu H, Yang Z, Yu Q, Zhao L, Wang Y. Synergistic Effects of Cryptotanshinone and Senkyunolide I in Guanxinning Tablet Against Endogenous Thrombus Formation in Zebrafish. Front Pharmacol. 2021;11:622787. Published 2021 Jan 14. doi:10.3389/fphar.2020.6 55. Hu, Y., Wang, X., Li, Q., Pan, Y., Xu, L."Salvianolic acid B alleviates myocardial ischemic injury by promoting mitophagy and inhibiting activation of the NLRP3 inflammasome". Molecular Medicine Reports 22.6 (2020): 5199-5208.https://doi.org/10.3892/mmr.20 56. Zhang, Xianhua, et al. "Danshen-Chuanxiong-Honghua ameliorates cerebral impairment and improves spatial cognitive deficits after transient focal ischemia and identification of active compounds." Frontiers in pharmacology 8 (2017): 452. 57. Zhang, Xianhua, et al. "Danshen-Chuanxiong-Honghua ameliorates cerebral impairment and improves spatial cognitive deficits after transient focal ischemia and identification of active compounds." Frontiers in pharmacology 8 (2017): 452. 58. Wang, Jixia, et al. "Discovery of new targets of phenolic acids in danshen using a label-free cell phenotypic assay." RSC Advances 5.33 (2015): 25768-25776.https://doi.org/10.1039/C4RA16102E 59. [IF=3.845] Zhang Xianhua et al."Danshen-Chuanxiong-Honghua Ameliorates Cerebral Impairment and Improves Spatial Cognitive Deficits after Transient Focal Ischemia and Identification of Active Compounds."Front Pharmacol. 2017 Jul;0:452 60. [IF=3.845] Zhang Xianhua et al."Danshen-Chuanxiong-Honghua Ameliorates Cerebral Impairment and Improves Spatial Cognitive Deficits after Transient Focal Ischemia and Identification of Active Compounds."Front Pharmacol. 2017 Jul;0:452 61. [IF=3.205] Xianhua Zhang et al."Pharmacokinetic study of representative anti-oxidative compounds from Denshen-Chuanxiong-Honghua following oral administration in rats."J Chromatogr B. 2017 May;1052:82 62. [IF=3.049] Jixia Wang et al."Discovery of new targets of phenolic acids in danshen using a label-free cell phenotypic assay."Rsc Adv. 2015 Mar;5(33):25768-25776 63. [IF=2.943] Zheng Chunli et al."System-level multi-target drug discovery from natural products with applications to cardiovascular diseases."Mol Divers. 2014 Aug;18(3):621-635 64. [IF=6.529] Weiyi Cao et al."Drug-drug interactions between salvianolate injection and aspirin based on their metabolic enzymes."Biomed Pharmacother. 2021 Mar;135:111203 65. [IF=5.81] Jun Li et al."Synergistic Effects of Cryptotanshinone and Senkyunolide I in Guanxinning Tablet Against Endogenous Thrombus Formation in Zebrafish."Front Pharmacol. 2020; 11: 622787 66. [IF=5.753] Yaping Xiang et al."Integrative Omics Analyses Reveal the Effects of Copper Ions on Salvianolic Acid Biosynthesis."Front Plant Sci. 2021; 12: 746117 67. [IF=4.759] Lu-lu Xu et al."Rapid quantitation and identification of the chemical constituents in Danhong Injection by liquid chromatography coupled with orbitrap mass spectrometry."J Chromatogr A. 2019 Nov;1606:460378 68. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625 69. [IF=4.759] Junjie Feng et al."An integrated data filtering and identification strategy for rapid profiling of chemical constituents, with Arnebiae Radix as an example."J Chromatogr A. 2020 Oct;1629:461496 70. [IF=4.432] Dong Wang et al."Salvianolic acid B attenuates oxidative stress-induced injuries in enterocytes by activating Akt/GSK3β signaling and preserving mitochondrial function."Eur J Pharmacol. 2021 Oct;909:174408 71. [IF=4.36] Jing Chen et al."Salvianolic acid B and ferulic acid synergistically promote angiogenesis in HUVECs and zebrafish via regulating VEGF signaling."J Ethnopharmacol. 2021 Sep;:114667 72. [IF=4.162] Weixin Hou et al."The Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats."Drug Des Dev Ther. 2021; 15: 3845–3862 73. [IF=4.074] Jia Li et al."Omics and Transgenic Analyses Reveal that Salvianolic Acid B Exhibits its Anti-Inflammatory Effects through Inhibiting the Mincle-Syk-Related Pathway in Macrophages."J Proteome Res. 2021;XXXX(XXX):XXX-XXX 74. [IF=3.765] Shun Liu et al."Simultaneous determination of seven effective components in Shenkui Tongmai granules based on UHPLC-MS/MS."J Pharm Pharmacol. 2021 Apr;73(6):758-766 75. [IF=3.411] Liu Hongyan et al."Effect Study of Continuous Monoculture on the Quality of Salvia miltiorrhiza Bge Roots."Biomed Res Int. 2020;2020:4284385 76. [IF=2.1] Yang Hu et al."Salvianolic acid B alleviates myocardial ischemic injury by promoting mitophagy and inhibiting activation of the NLRP3 inflammasome."Mol Med Rep. 2020 Dec;22(6):5199-5208 77. [IF=1.885] Cao Weiyi et al."Simultaneous Quantification of Aspirin, Its Metabolite Salicylic Acid, and Salvianolic Acid B in Human Plasma Using UPLC-MS/MS."Int J Anal Chem. 2021;2021:6620868 78. [IF=7.848] Mingyue Zhou et al."Oriented Layered Graphene Oxide Pad Favoring High Loading Capacity and Stability for High-Throughput Chemical Screening."Advanced Materials Technologies. 2022 Mar 11 79. [IF=5.875] Yutong Wang et al."Extra virgin olive oil-based phospholipid complex/self-microemulsion enhances oral absorption of salvianolic acid B through inhibition of catechol-O-methyltransferase-mediated metabolism."Int J Pharmaceut. 2022 Jan;611:121330 80. [IF=9.078] Jun Qian et al."A strategy for effective recovery of salvianolic acid a from Salvia miltiorrhiza (Danshen) through multiple interactions."Compos Part B-Eng. 2022 Feb;231:109563 81. [IF=11.614] Yanqiu Gu et al."In situ synthesis and unidirectional insertion of membrane proteins in liposome-immobilized silica stationary phase for rapid preparation of microaffinity chromatography."Acta Pharmaceutica Sinica B. 2022 Apr;: 82. [IF=6.598] Peng Lu et al."Salvianolic acid B dry powder inhaler for the treatment of idiopathic pulmonary fibrosis."Asian Journal of Pharmaceutical Sciences. 2022 Apr;: 83. [IF=3.935] Yaqing Guo et al."An integrated strategy for the systematic chemical characterization of Salvianolate lyophilized injection using four scan modes based on the ultra-high performance liquid chromatography-triple quadrupole-linear ion trap mass spectrometry. |
115939-25-8 - Reference Information
| overview | cardiovascular disease is a serious threat to human health. the disease has the characteristics of "high morbidity, high disability and high mortality" and has become the number one cause of human death. Therefore, finding drugs that can effectively treat cardiovascular diseases has become the primary clinical problem. The traditional Chinese medicine for promoting blood circulation and removing blood stasis has been widely used in the treatment of cardiovascular diseases because of its effects of removing blood stasis and pain, promoting blood circulation and dredging meridian. Studies have found that salvianolic acid (salvianolicacids) is the most abundant water-soluble substance in Salvia miltiorrhiza (Latin scientific name: salviamiltiorrhizabunge), while salvianolic acid B is the compound with the most content and the strongest biological activity in salvianolic acid. Studies have shown that salvianolic acid not only has a protective effect on myocardial ischemia/reperfusion injury, but also has a protective effect on myocardial infarction and myocardial cell fertilization. |
| pharmacological action | protective effect of salvianolic acid B on myocardial infarction: a rat myocardial infarction (myocardialinfarction,MI) model was established by coronary artery ligation to investigate the protective effect of salvianolic acid B on MI. The results showed that compared with the control group, salvianolic acid B can exert obvious cardioprotective effect on MI. Mechanism studies show that salvianolic acid B mainly plays a role in protecting the heart by inhibiting the up-regulation of leptin and endothelin-reactive oxygen species (ET-ROS) and restoring the normal expression of sarcoplasmic reticulum calcium ATPase 2a(sarco/endoplasmicreticulumATPase2a,SERCA2a) and phosphoprotein in myocardial central muscle cells. salvianolic acid B has the effect of inhibiting myocardial cell hypertrophy: the effect of salvianolic acid B on myocardial cell hypertrophy induced by angiotensin Ⅱ(angiotensin Ⅱ,Ang Ⅱ) in neonatal rats was investigated. The results showed that salvianolic acid B can inhibit myocardial cell hypertrophy induced by Ang Ⅱ, and the expression of atrial natriuretic peptide and brain natriuretic peptide mRNA decreased and cell surface area decreased. Mechanism studies have found that salvianolic acid B can inhibit the activity of polyadenosine diphosphate ribose polymerase 1[poly(ADP-ribose)polymerase-1,PARP-1]. At the same time, it is found that overexpression PARP-1 can weaken the effect of salvianolic acid B on myocardial cell hypertrophy. These studies show that salvianolic acid B has a good effect on inhibiting myocardial cell hypertrophy. |
| chemical properties | white crystalline powder, soluble in water, ethanol and methanol, derived from salvia miltiorrhiza rhizome. |
| use | salvianolic acid B has antioxidant, heart protection, brain protection and anti-tumor effects. |
Last Update：2024-04-09 01:59:58
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CAS: 115939-25-8
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