1173721-45-3

1173721-45-3 - Names and Identifiers

Name	1H-Pyrrolo[2,3-b]pyridine-2,3-dione, 5-bromo-1-methyl-
Synonyms	5-Bromo-1-methylpyrrolo[2,3-b]pyridine-2,3-dione 5-broMo-1-Methyl-1H-pyrrolo[2,3-b]pyridine-2,3-dione 1H-Pyrrolo[2,3-b]pyridine-2,3-dione, 5-bromo-1-methyl- 1H-Pyrrolo[2,3-b]pyridine-2,3-dione, 5-broMo-1-Methyl- 5-bromo-1-methyl-1H,2H,3H-pyrrolo[2,3-b]pyridine-2,3-dione
CAS	1173721-45-3

1173721-45-3 - Physico-chemical Properties

Molecular Formula	C8H5BrN2O2
Molar Mass	241.04
Boling Point
Storage Condition	2-8°C

1173721-45-3 - Introduction

5-Bromo-1-methyl-1H-pyrrolo [2,3-b] pyridine-2, 3-dione, also known as BMPD, is an organic compound. Its chemical formula is C11H6BrNO2 and its relative molecular mass is 286.08g/mol. The following is an introduction to the nature, use, preparation and safety information of BMPD:

Nature:
-Appearance: BMPD is a white to pale yellow crystalline powder.
-Melting point: The melting point of BMPD is about 295-298°C.
-Solubility: BMPD is soluble in common solvents (such as ethanol, dimethyl sulfoxide, etc.), but has low solubility in water.

Use:
-As a drug intermediate: BMPD is an important drug intermediate, widely used in the field of drug synthesis. It can be used in the synthesis of a variety of pharmaceuticals, such as anti-tumor drugs, antiviral drugs.

Preparation Method:
-There are many ways to prepare BMPD, and the following is one of the commonly used synthetic routes:
1. First, 2,6-dibromopyridine is reacted with diethyl methylmalonate to obtain 2,6-dibromopyrrolo [2,3-b] pyridine.
2. Then, 2,6-dibromopyrrolo [2,3-b] pyridine is reacted with sodium tellurite, and the electrophilic substitution reaction of N-fluorene ortho occurs under the catalysis of base to obtain the target product 5-bromo -1-methyl -1H-pyrrolo [2,3-b] pyridine-2, 3-dione.

Safety Information:
- BMPD is relatively stable under normal operating conditions, but the following safety precautions still need to be paid attention:
1. contact: avoid direct contact with BMPD powder or solution and skin, eye contact. If contact occurs, rinse immediately with plenty of water and seek medical help.
2. inhalation: avoid inhalation of BMPD dust and vapor. Use ventilation equipment or wear respiratory protective equipment during operation.
3. combustion: BMPD may burn at high temperatures, producing toxic smoke. Keep away from open flames and high temperature sources.
4. Storage: BMPD should be stored in a dry, cool, well-ventilated place, away from fire and oxidant.

It should be noted that BMPD is an organic compound with certain toxicity and danger. Therefore, it is necessary to follow relevant safety procedures when using and handling, and strictly control its use and storage.

Last Update：2024-04-09 21:01:54