| Molecular Formula | C30H30O7
|
| Molar Mass | 502.55 |
| Density | 1.235±0.06 g/cm3(Predicted) |
| Melting Point | 151-152 °C |
| Boling Point | 753.8±60.0 °C(Predicted) |
| Solubility | Chloroform (Slightly, Heated, Sonicated), DMSO (Very Slightly) |
| pKa | 3.81±0.10(Predicted) |
| Storage Condition | -20°C Freezer |
| Use | LY223982 is a potent, specific leukotriene B4 receptor inhibitor that effectively inhibits [3H]LTB4 from binding to LTB4 receptor with an IC50 value of 13.2 |
| In vitro study | LY223982 is a potent and specific inhibitor of leukotriene B4 (LTB4) receptor, with an IC 50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. LY223982 is also a potent antagonist of the aggregation of human neutrophils by LTB4 (IC 50 , 100 nM). |
| In vivo study | LY223982 inhibits transient leukopenia induced in rabbits with LTB4 (ED 50 , 3 mg/kg) but not with FMLP, and shows no agonist activity in any of the test systems. |
