1186189-28-5
Ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate
CAS: 1186189-28-5
Molecular Formula: C11H10N2O4
1186189-28-5 - Names and Identifiers
1186189-28-5 - Physico-chemical Properties
| Molecular Formula | C11H10N2O4 |
| Molar Mass | 234.21 |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Boling Point | 388.1±52.0 °C(Predicted) |
| pKa | 4.50±1.00(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | IRRITANT |
| MDL | MFCD17011899 |
1186189-28-5 - Risk and Safety
| Hazard Class | IRRITANT |
1186189-28-5 - Introduction
Ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate is a compound with the formula C14H11NO5. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: white or off-white crystalline powder;
-Molecular weight: 277.24g/mol;
-Melting point: 160-163°C;
-Solubility: Soluble in alcohol and ester solvents, slightly soluble in water.
Use:
Ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate has a variety of uses in chemical research and synthesis, including:
-as a drug intermediate: can be used for the synthesis of antibacterial agents, antiviral drugs, etc;
-Can be used to synthesize organic photoelectric materials and dyes.
Preparation Method:
Ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate is prepared as follows:
1. First, the reaction of 1,8-naphthyridine and ethanol aldehyde generates hydroxypyruvate;
2. then, reacting hydroxypyruvate with hydroxylamine to form aminopyruvate;
3. Finally, Ethyl 4-hydroxy-2-oxo-1, 2-dihydroxy-1, 8-naphthyridine-3-carboxylate can be obtained by reacting aminopyruvate with dicarboxylic anhydride (such as phthalic acid).
Safety Information:
Ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate has not been specifically reported for safety information. Please follow the following general safety operations when using:
-In the process of use, pay attention to personal protection, such as wearing chemical protective glasses and gloves;
-Keep the laboratory well ventilated and avoid inhaling its dust;
-Avoid contact with combustibles and keep away from open flames or high temperature environments;
-During storage, keep sealed and store in a dry, cool place.
Please note that only basic information is provided in this article. Please refer to relevant literature and materials for specific use and operation, and comply with laboratory safety practices.
Nature:
-Appearance: white or off-white crystalline powder;
-Molecular weight: 277.24g/mol;
-Melting point: 160-163°C;
-Solubility: Soluble in alcohol and ester solvents, slightly soluble in water.
Use:
Ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate has a variety of uses in chemical research and synthesis, including:
-as a drug intermediate: can be used for the synthesis of antibacterial agents, antiviral drugs, etc;
-Can be used to synthesize organic photoelectric materials and dyes.
Preparation Method:
Ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate is prepared as follows:
1. First, the reaction of 1,8-naphthyridine and ethanol aldehyde generates hydroxypyruvate;
2. then, reacting hydroxypyruvate with hydroxylamine to form aminopyruvate;
3. Finally, Ethyl 4-hydroxy-2-oxo-1, 2-dihydroxy-1, 8-naphthyridine-3-carboxylate can be obtained by reacting aminopyruvate with dicarboxylic anhydride (such as phthalic acid).
Safety Information:
Ethyl 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate has not been specifically reported for safety information. Please follow the following general safety operations when using:
-In the process of use, pay attention to personal protection, such as wearing chemical protective glasses and gloves;
-Keep the laboratory well ventilated and avoid inhaling its dust;
-Avoid contact with combustibles and keep away from open flames or high temperature environments;
-During storage, keep sealed and store in a dry, cool place.
Please note that only basic information is provided in this article. Please refer to relevant literature and materials for specific use and operation, and comply with laboratory safety practices.
Last Update：2024-04-09 21:01:54
