1191900-51-2

Name	Brexpiprazole sulfoxide impurity
Synonyms	DM-3411 Epipiprazole862 Brexpiprazole S-Oxide Brexpiprazole Sulfoxide Brexpiprazole sulfoxide (Crude) Brexpiprazole sulfoxide impurity 7-[4-[4-(1-oxo-1-benzothiophen-4-yl)piperazin-1-yl]butoxy]-1H-quinolin-2-one 2(1H)-Quinolinone, 7-[4-[4-(1-oxidobenzo[b]thien-4-yl)-1-piperazinyl]butoxy]-
CAS	1191900-51-2

biological activity	Brexpiprazole S-oxide (DM-3411) is the main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole, an atypical antipsychotic, is a partial agonist of human 5-HT1A and dopamine receptors with Ki of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also an antagonist of 5-HT2A receptor, Ki is 0.47 nM.
target	5-HT 1A Receptor 0.12 nM (Ki) 5-HT 2A Receptor 0.47 nM (Ki) D 2 Receptor 0.3 nM (Ki)

Last Update：2024-04-09 21:11:58

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1191900-51-2

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