1197824-15-9
EN4 MYC inhibitor
CAS: 1197824-15-9
Molecular Formula: C25H24N2O4
1197824-15-9 - Names and Identifiers
| Name | EN4 MYC inhibitor |
| Synonyms | EN4 MYC inhibitor Benzamide, N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]- |
| CAS | 1197824-15-9 |
1197824-15-9 - Physico-chemical Properties
| Molecular Formula | C25H24N2O4 |
| Molar Mass | 416.47 |
| Density | 1.202±0.06 g/cm3(Predicted) |
| Boling Point | 564.1±50.0 °C(Predicted) |
| pKa | 12.82±0.70(Predicted) |
| Storage Condition | -20℃ |
| Use | EN4 is a functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. EN4 functionally and covalently targets an intrinsically disordered region in MYC. EN4 directly targets MYC in cells and reduces MYC and MAX thermal stability. EN4 inhibits MYC activity, downregulates MYC targets, and impairs tumorigenesis. MYC is a major oncogenic transcriptional driver of most human cancers that has remained intractable to direct targeting because much of MYC is intrinsically disordered. |
1197824-15-9 - Reference
| Reference Show more | Boike L, Cioffi AG, Majewski FC, Co J, Henning NJ, Jones MD, Liu G, McKenna JM, Tallarico JA, Schirle M, Nomura DK. Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. Cell Chem Biol. 2021 Jan 21;28(1):4-13.e17. doi: 10.1016/j.chembiol.2020.09.001. Epub 2020 Sep 22. PMID: 32966806; PMCID: PMC7854864. |
1197824-15-9 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.401 ml | 12.006 ml | 24.011 ml |
| 5 mM | 0.48 ml | 2.401 ml | 4.802 ml |
| 10 mM | 0.24 ml | 1.201 ml | 2.401 ml |
| 5 mM | 0.048 ml | 0.24 ml | 0.48 ml |
Last Update：2024-01-02 23:10:35
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Product Name: EN4 MYC inhibitor Visit Supplier Webpage Request for quotationCAS: 1197824-15-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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