overview | eplerenone is a new and selective aldosterone antagonist, which can be directly combined with aldosterone to inhibit its effect. the effect is similar to spironolactone, and long-term administration has slight adverse reactions to gonads. Eplerenone is mainly used to treat essential hypertension and heart failure after myocardial infarction. It is also the first selective aldosterone receptor blocker approved for marketing. 11A-hydroxycanritone methyl acrylate is an intermediate in the preparation of eplerenone. |