Molecular Formula | C34H31CuN4NaO6(-2) |
Molar Mass | 678.18 |
Melting Point | >300°C |
Boling Point | 801.6℃ at 760 mmHg |
Water Solubility | Soluble in water. |
Solubility | DMSO (Slightly), Methanol (Very Slightly) |
Appearance | Dark green powder |
Color | Dark Green to Black |
Exposure Limit | ACGIH: TWA 1 mg/m3NIOSH: IDLH 100 mg/m3; TWA 1 mg/m3 |
Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
Sensitive | Sensitive to light |
MDL | MFCD00012149 |
Use | Used as food colorants and medical raw materials, it has the function of promoting the healing of gastrointestinal ulcer surface in medical treatment. |
Risk Codes | 62 - Possible risk of impaired fertility |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 2 |
RTECS | GS2168866 |
TSCA | Yes |
HS Code | 32129000 |
Reference Show more | 1. Wu Yue, Yang Jing, Zhang Guocai, et al. Antimicrobial activity and stability of sodium copper chlorophyllin [J]. Journal of Northwest Forestry University, 2020, v.35;No.163(03):147-152. 2. Wang Na, Du Yuan, Huang Haidong, Guo Jinai. Dyeing of Wool, Silk and Nylon Knitted Fabrics with Copper Chlorophyll Sodium Salt [J]. Knitting Industry, 2020(10):37-40. 3. Dou Fangfang, Gong Xiaoqing, Zou Yangjun. Isolation and Functional Identification of Apple Ubiquitin Protein MdRAD23C2 Gene [J]. Journal of Northwest Agriculture and Forestry University (Natural Science Edition), 2019(11). 4. Lu, Caicai, et al. "Chlorophyll as natural redox mediators for the denitrification process." International Biodeterioration & Biodegradation 148 (2020): 104895.https://doi.org/10.1016/j.ibiod. 2020.104895 5. [IF=4.32] Caicai Lu et al."Chlorophyll as natural redox mediators for the denitrification process."Int Biodeter Biodegr. 2020 Mar;148:104895 |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
properties | dark green powder, extracted from silkworm excrement clock, water soluble pigment. |
stability | copper sodium chlorophyllin is a semi-synthetic pigment, which is between synthetic pigment and natural pigment in terms of stability, but its potential functionality is richer and its comprehensive value is higher. |
Uses | The application of sodium copper chlorophyllin in drugs is relatively mature and is currently involved in many functional fields. Medical research pointed out that sodium copper chloroplast has the following uses: 1. Protecting the liver, sodium copper chloroplast has a significant antioxidant effect, which can help the liver protect human somatic cells from free radicals and oxidative stress attacks, reduce the burden on the liver, and also It can activate liver reticuloendothelial cells, promote the recovery of liver function, and enhance the resistance of liver cell function; 2. Prevent leukopenia and anemia. The reasons for leukopenia are very complicated, the indications are often symptomatic treatment, and the improvement of sodium copper chlorophyllin is universal. According to incomplete statistics, the effective rate of sodium copper chloroplast in clinical trials is as high as more than 80%; 3. Ulcer and wound repair, sodium copper chloroplast is absorbed quickly in the human body, which can promote the metabolism of body cells and have a significant effect on body repair. 4. Anti-mutation, sodium copper chloroplast has an inhibitory effect on the activity of various mutagens such as benzopyrene, and can also improve cell activity, increase the phagocytic ability of macrophages, and improve the body's ability to resist mutations. It is used as a food colorant and pharmaceutical raw material, and has the functions of promoting the healing of gastrointestinal ulcer surface in medical treatment |
application | copper sodium chlorophyllin can be applied to more than a dozen food categories such as frozen drinks, canned vegetables, candy, baked goods, fruit and vegetable juice drinks, jelly, etc. in China, among which there is no limit in fruit and vegetable juice drinks, and the maximum in other categories is 0.5 g/kg. |
preparation | silkworm sand or green tea leaves are dried at 40-50 ℃, ground into powder, added with 3 times the powder amount of ethanol and acetone mixture (1:1) and extracted at 40-50 ℃ for 1.5h, filtered by suction, and the filter residue is extracted again with equal volume of ethanol and acetone mixture. Add sodium hydroxide to adjust the pH to 11, and heat (50 ℃) saponification for 30min. After saponification, the mixed solution (60 ℃) was distilled and concentrated to recover to the original volume of 1/4-1/3, and then extracted with petroleum ether for 4 times. The lower layer is adjusted to pH 7 with hydrochloric acid, adjusted to pH 2 after adding copper sulfate, and replaced with copper at 50 ℃ for 1h. It is allowed to stand for cooling and granular precipitation is formed. The precipitate is collected at room temperature, washed with 50-60 ℃ water, washed with 30%-40% ethanol until the ethanol layer is light green, and then washed with petroleum ether until the oil layer is light green. The filter cake is dissolved with acetone, precipitated with 5% sodium hydroxide ethanol solution, pH 12, collected and washed with absolute ethanol to obtain sodium copper chloroplast. |
biological activity | Chlorophyllin is a chlorophyll sodium copper salt form, which is an antioxidant and antimutagenic agent. |