120608-58-4
2-Fluorobenzylmagnesium chloride
CAS: 120608-58-4
Molecular Formula: C7H6ClFMg
120608-58-4 - Names and Identifiers
120608-58-4 - Physico-chemical Properties
| Molecular Formula | C7H6ClFMg |
| Molar Mass | 168.88 |
| Sensitive | Air & Moisture Sensitive |
120608-58-4 - Risk and Safety
| Hazard Symbols | F - Flammable |
| Hazard Class | 3 |
120608-58-4 - Introduction
2-Fluorobenzylmagnesium chloride (2-Fluorobenzylmagnesium chloride) is an organic magnesium compound. Its chemical formula is C7H6ClF Mg and its molecular weight is 172.84g/mol. The following is a description of some properties, uses, preparation and safety information about this compound:
Nature:
-Appearance: 2-Fluorobenzylmagnesium chloride are colorless or pale yellow crystals.
-Solubility: It is soluble in inert organic solvents (such as ether, tetrahydrofuran, etc.).
-Stability: 2-Fluorobenzylmagnesium is chloride stable in moisture, but is easily affected by moisture in the air.
-Ignition point: This compound has a low ignition point and needs to be handled and stored under conditions consistent with safe operation.
Use:
2-Fluorobenzylmagnesium chloride has a wide range of applications in organic synthesis and is commonly used in the following reactions:
-According to the characteristics of Grignard reagents, it can undergo nucleophilic addition reactions with various halogenated hydrocarbons or halogenated aromatic hydrocarbons to generate corresponding organic magnesium reagents.
-Reacts with acid salts or ketones to form alcohols or alkoxides.
-For functional group reaction of aromatic compounds, such as esterification, etherification, ketonization, etc.
Preparation Method:
The preparation of 2-Fluorobenzylmagnesium chloride is generally carried out by the following steps:
1. Add benzyl magnesium chloride (PhCH2Cl) to dry tetrahydrofuran.
2. 2-fluorobenzeneboronic acid (C6H4BF3) was added to tetrahydrofuran.
3. The reaction mixture is slowly heated, usually under reflux conditions.
4. After completion of the reaction, the reaction mixture is treated with an acid (e. g., dilute hydrochloric acid) to obtain the product.
Safety Information:
- 2-Fluorobenzylmagnesium chloride is a flammable compound. When handling, you should follow safe operating procedures and keep away from open flames and heat sources.
-Need to operate in a well-ventilated place to avoid inhaling its gas or dust.
-Wear appropriate personal protective equipment when using, including safety glasses, gloves and lab coats.
-If you touch your skin or eyes by accident, rinse immediately with plenty of water and seek medical help.
-Store it in a dry, cold and dark place, separate from oxidants and acids to prevent dangerous reactions.
Nature:
-Appearance: 2-Fluorobenzylmagnesium chloride are colorless or pale yellow crystals.
-Solubility: It is soluble in inert organic solvents (such as ether, tetrahydrofuran, etc.).
-Stability: 2-Fluorobenzylmagnesium is chloride stable in moisture, but is easily affected by moisture in the air.
-Ignition point: This compound has a low ignition point and needs to be handled and stored under conditions consistent with safe operation.
Use:
2-Fluorobenzylmagnesium chloride has a wide range of applications in organic synthesis and is commonly used in the following reactions:
-According to the characteristics of Grignard reagents, it can undergo nucleophilic addition reactions with various halogenated hydrocarbons or halogenated aromatic hydrocarbons to generate corresponding organic magnesium reagents.
-Reacts with acid salts or ketones to form alcohols or alkoxides.
-For functional group reaction of aromatic compounds, such as esterification, etherification, ketonization, etc.
Preparation Method:
The preparation of 2-Fluorobenzylmagnesium chloride is generally carried out by the following steps:
1. Add benzyl magnesium chloride (PhCH2Cl) to dry tetrahydrofuran.
2. 2-fluorobenzeneboronic acid (C6H4BF3) was added to tetrahydrofuran.
3. The reaction mixture is slowly heated, usually under reflux conditions.
4. After completion of the reaction, the reaction mixture is treated with an acid (e. g., dilute hydrochloric acid) to obtain the product.
Safety Information:
- 2-Fluorobenzylmagnesium chloride is a flammable compound. When handling, you should follow safe operating procedures and keep away from open flames and heat sources.
-Need to operate in a well-ventilated place to avoid inhaling its gas or dust.
-Wear appropriate personal protective equipment when using, including safety glasses, gloves and lab coats.
-If you touch your skin or eyes by accident, rinse immediately with plenty of water and seek medical help.
-Store it in a dry, cold and dark place, separate from oxidants and acids to prevent dangerous reactions.
Last Update：2024-04-10 22:29:15
