Mal-PEG-Amine,NH2-PEG-MAL(Mal-PEG-Amine,NH2-PEG-MAL) is a compound formed by linking polyethylene glycol (PEG) and maleimide (Maleimide) groups.
Mal-PEG-Amine,NH2-PEG-MAL is a reactive substance in chemical properties. The maleimide group has the ability to react with the thiol group (-SH), and can react with the thiol functional compound to form a stable covalent bond by Michael addition reaction. The amino group has affinity and can hydrogen bond or electrostatic interaction with other molecules or surfaces.
Mal-PEG-Amine, the main use of NH2-PEG-MAL is as a functional modifier for biomaterials or drug delivery vehicles in the biomedical field. It can be covalently bound to biomolecules or drugs to provide stability, improve solubility and regulate their release rate. In addition, it can also be used in the preparation of biosensors, nanoparticles, polymer grafting and other applications.
Preparation of Mal-PEG-Amine,NH2-PEG-MAL can be achieved by the chemical reaction of PEG and maleimide. One common method is to react maleimidoyl chloride with polyethylene glycol amine under basic conditions to give the product.
In the use of Mal-PEG-Amine,NH2-PEG-MAL need to pay attention to its safety information. Due to the reactivity of the compounds, care should be taken to avoid contact with skin, eyes or inhalation of aerosols. Operate in well-ventilated conditions and wear appropriate personal protective equipment.