1211-35-4 - Names and Identifiers
1211-35-4 - Physico-chemical Properties
Molecular Formula | C14H10ClN
|
Molar Mass | 227.69 |
Density | 1.271±0.06 g/cm3(Predicted) |
Melting Point | 203 °C |
Boling Point | 417.8±20.0 °C(Predicted) |
Flash Point | 239°C |
Vapor Presure | 8.36E-07mmHg at 25°C |
pKa | 16.29±0.30(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.684 |
MDL | MFCD00047159 |
1211-35-4 - Risk and Safety
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38 - Irritating to eyes, respiratory system and skin.
R22 - Harmful if swallowed
|
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39 - Wear suitable gloves and eye/face protection
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
|
HS Code | 29339900 |
1211-35-4 - Introduction
2-(4-Chlorophenyl) indole is an organic compound with the chemical formula C14H9ClN. It is a white to pale yellow crystalline solid. The following is a description of the properties, uses, preparation and safety information of 2-(4-chlorophenyl) indole:
Nature:
-Appearance: White to light yellow crystalline solid.
-Melting point: about 130-132 ℃.
-Solubility: Soluble in chloroform, ethanol, dichloromethane and other organic solvents, slightly soluble in water.
-Chemical reaction: 2-(4-chlorophenyl) indole can undergo a variety of organic reactions, such as substitution reactions and cyclization reactions.
Use:
-As an intermediate: 2-(4-chlorophenyl) indole can be used as an important intermediate in organic synthesis. It can participate in a variety of organic synthesis reactions, for the preparation of natural products containing indole structure, drugs and pesticides and other compounds.
-Drug research: Due to the special properties of its indole structure, 2-(4-chlorophenyl) indole has a wide range of applications in the field of drug research. It is used for the research and development and synthesis of anticancer drugs, antibacterial drugs, etc.
Preparation Method:
2-(4-chlorophenyl) indole preparation methods are mainly the following:
-Substitution reaction: 2-(4-chlorophenyl) indole is generated by reacting 2-indole base with 4-chlorophenyl bromide or chloride using sodium bicarbonate as an auxiliary base catalyst.
-Indole cyclization reaction: 2-(4-chlorophenyl) indole is generated by reaction of unsaturated compound with 4-chlorophenyl ketone and cyclization reaction.
Safety Information:
- 2-(4-chlorophenyl) indole has low toxicity, but it is still necessary to pay attention to safety precautions during use.
-Avoid contact with skin, eyes and respiratory tract, and maintain good ventilation during operation.
-Avoid contact with oxidants and acids during handling or storage.
-If you inhale or come into contact with the substance, wash the affected area immediately and seek medical help.
Last Update:2024-04-09 15:17:51