121104-96-9
Celgosivir
CAS: 121104-96-9
Molecular Formula: C12H21NO5
121104-96-9 - Names and Identifiers
| Name | Celgosivir |
| Synonyms | MBI 3253 MDL28574 MDL-28574 MDL 28574 celgosivir Celgosivir (1S)-1,2,3,5,6,7,8,8aα-Octahydro-6α-butyryloxyindolizine-1β,7β,8α-triol |
| CAS | 121104-96-9 |
121104-96-9 - Physico-chemical Properties
| Molecular Formula | C12H21NO5 |
| Molar Mass | 259.3 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Melting Point | 114-115 °C |
| Boling Point | 422.9±45.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| Appearance | Solid |
| Color | White to Pale Beige |
| pKa | 13.14±0.70(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| MDL | MFCD00886617 |
| In vitro study | Celgosivir is more effective (IC 50 =20 μM) than the parent molecule (IC 50 =254 μM) at causing the accumulation of glucosylated oligosaccharides in HIV-infected cells by inhibition of glycoprotein processing. Celgosivir exhibits potent antiviral activity against HIV-1 with an IC 50 of 2.0±2.3 μM. Bovine viral diarrhoea virus (BVDV) is a closely related virus of hepatitis C virus (HCV). Celgosivir inhibits BVDV with IC 50 values of 16 and 47 μM in plaque assay and cytopathic effect assay, respectively. Celgosivir inhibits DENV2 replication with an EC 50 of 0.2 μM. The EC 50 values against DENV1, 3 and 4 are less than 0.7 μM. |
| In vivo study | Celgosivir fully protects AG129 mice from lethal infection with a mouse adapted dengue virus at a dose of 50 mg/kg twice daily (BID) for 5 days and is effective even after 48 h delayed treatment. The protection by celgosivir is dose- and schedule-dependent and that a twice-a-day regimen of 50, 25 or 10 mg/kg is more protective than a single daily dose of 100 mg/kg. Pharmacokinetics studies of celgosivir in mice shows that it rapidly metabolizes to castanospermine. During primary infection with a mouse-adapted DENV strain S221, mice shows increased viremia on day 3, yet 80% survived day 10 with virus completely cleared by day 8. |
121104-96-9 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.857 ml | 19.283 ml | 38.565 ml |
| 5 mM | 0.771 ml | 3.857 ml | 7.713 ml |
| 10 mM | 0.386 ml | 1.928 ml | 3.857 ml |
| 5 mM | 0.077 ml | 0.386 ml | 0.771 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Product Name: Celgosivir Visit Supplier Webpage Request for quotation
CAS: 121104-96-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 121104-96-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Celgosivir Visit Supplier Webpage Request for quotation
CAS: 121104-96-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 121104-96-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History