1214265-56-1
WZ3146
CAS: 1214265-56-1
Molecular Formula: C24H25ClN6O2
1214265-56-1 - Names and Identifiers
1214265-56-1 - Physico-chemical Properties
| Molecular Formula | C24H25ClN6O2 |
| Molar Mass | 464.95 |
| Density | 1.318 |
| pKa | 12.78±0.70(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | WZ3146 acts on Ba/F3 cells, selectively inhibiting EGFR L858R, EGFR E746_A750, EGFR L858R/T790M and EGFR E746_A750/T790M phosphorylation, IC50 is 2 nM, 2 nM, respectively, 5 nM and 14 nM. WZ3146 significantly inhibited the growth of cell lines containing EGFR mutation. When WZ3146 acted on HCC827 cells containing EGFR Del E746_A750, The IC50 was 3 nM, and when WZ3146 acted on PC9 cells containing EGFR Del E746_A750, The IC50 was 15 nM, for H1975 cells containing EGFR L858R/T790M, The IC50 was 29 nM, and for PC9 GR cells containing EGFR Del E746_A750/T790M, The IC50 was 3 nM. |
1214265-56-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.151 ml | 10.754 ml | 21.507 ml |
| 5 mM | 0.43 ml | 2.151 ml | 4.301 ml |
| 10 mM | 0.215 ml | 1.075 ml | 2.151 ml |
| 5 mM | 0.043 ml | 0.215 ml | 0.43 ml |
Last Update：2024-01-02 23:10:35
1214265-56-1 - Reference Information
| biological activity | WZ3146 is a mutation-selective, irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750), IC50 was 2 nM and 2 nM, respectively; There was no inhibition of ERBB2 phosphorylation (T798I). |
| Feature | Mutant-selective, irreversible. |
Last Update：2024-04-09 15:16:56
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Product Name: WZ3146 Visit Supplier Webpage Request for quotationCAS: 1214265-56-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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