1217500-90-7
(2-Carbamoyl-4-fluorophenyl)boronic acid
CAS: 1217500-90-7
Molecular Formula: C7H7BFNO3
1217500-90-7 - Names and Identifiers
1217500-90-7 - Physico-chemical Properties
| Molecular Formula | C7H7BFNO3 |
| Molar Mass | 182.94 |
| Storage Condition | 2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD12546533 |
1217500-90-7 - Introduction
boronic acid is an organic boron compound with the chemical formula C7H7BFNO3. It is a white solid, soluble in many organic solvents such as methanol, ethanol and dimethylformamide.
boronic acid is widely used in the field of organic synthesis. It is an important boronic acid coupling reagent that can be used to construct carbon-carbon bonds and carbon-boron bonds. It can react with aromatic and aliphatic halogenated hydrocarbons to form the corresponding borate esters. These boronic acid esters can be used as important intermediates for the synthesis of drugs, dyes and pesticides and other organic compounds.
The synthesis of boronic acid generally involves two steps. First, 2-carbamoyl-4-fluorophenyl bromide is reacted with triphenylphosphonium borate to form the corresponding boronic ester. Then, using sodium carbonate as the base catalyst, the borate ester is hydrolyzed to obtain the final product.
For safety information, boronic acid should be handled and stored in accordance with chemical safety procedures. It will produce toxic gas when decomposed at high temperature, so it should be prevented from contact with strong oxidants, oxidizing substances and high temperature. During use, avoid direct contact with skin and eyes, and wear personal protective equipment such as protective gloves and goggles. In case of inhalation or skin contact, rinse immediately with plenty of water and seek medical help. Detailed safety information and operating instructions can be found in the safety data sheets provided by the chemical supplier.
boronic acid is widely used in the field of organic synthesis. It is an important boronic acid coupling reagent that can be used to construct carbon-carbon bonds and carbon-boron bonds. It can react with aromatic and aliphatic halogenated hydrocarbons to form the corresponding borate esters. These boronic acid esters can be used as important intermediates for the synthesis of drugs, dyes and pesticides and other organic compounds.
The synthesis of boronic acid generally involves two steps. First, 2-carbamoyl-4-fluorophenyl bromide is reacted with triphenylphosphonium borate to form the corresponding boronic ester. Then, using sodium carbonate as the base catalyst, the borate ester is hydrolyzed to obtain the final product.
For safety information, boronic acid should be handled and stored in accordance with chemical safety procedures. It will produce toxic gas when decomposed at high temperature, so it should be prevented from contact with strong oxidants, oxidizing substances and high temperature. During use, avoid direct contact with skin and eyes, and wear personal protective equipment such as protective gloves and goggles. In case of inhalation or skin contact, rinse immediately with plenty of water and seek medical help. Detailed safety information and operating instructions can be found in the safety data sheets provided by the chemical supplier.
Last Update：2024-04-09 21:01:54
